Abdominal sarcoidosis presenting as bilateral simultaneous optic disc granulomas

Source: Neuro-Ophthalmology - Category: Opthalmology Authors: Source Type: research

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ConclusionsICD placement in CS is associated with high incidence of both appropriate and inappropriate therapy. High degree AV block appears to be predictive of appropriate ICD therapy.
Source: Journal of Interventional Cardiac Electrophysiology - Category: Cardiology Source Type: research
ConclusionsIn this study, high serum adiponectin level was detected in patients with sarcoidosis while serum leptin level was similar in the sarcoidosis and control group. Adiponectin, an anti-inflammatory protein, may play a role in the pathogenesis of sarcoidosis. Studies are needed to shed light on this topic.Key Points• Sarcoidosis is a chronic granulomatous disease characterized by granuloma formation• High serum adiponectin level was found in sarcoidosis patients• Serum adiponectin level was associated with some clinical features such as arthralgia and arthritis• High adiponectin levels in sarcoid...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
Source: Journal of Nuclear Cardiology - Category: Nuclear Medicine Source Type: research
Source: Journal of Nuclear Cardiology - Category: Nuclear Medicine Source Type: research
We have read with great interest the study by Huitema et al. [1] showing a pulmonary hypertension (PH) prevalence of around 3% in a large cohort of predominantly Caucasian sarcoidosis patients in a Dutch tertiary centre. According to the authors, a European Caucasian cohort has never been studied before this PULmonary hypertension in pulmonary SARcoidosis (PULSAR) study. In this context, in 2013 we reported another PULSAR study (PULmonary hypertension in SARcoidosis) in an albeit smaller cohort from a German tertiary centre [2]. Of interest, we showed very similar results, with a prevalence of precapillary PH of 3.6% with ...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Original Articles: Correspondence Source Type: research
AbstractFindings from molecular studies suggesting that several infectious agents cause sarcoidosis are intriguing yet conflicting and likely biased due to their cross-sectional design. As done in other inflammatory diseases to overcome this issue, prospectively-collected register data could be used, but reverse causation is a threat when the onset of disease is difficult to establish. We investigated the association between infectious diseases and sarcoidosis to understand if they are etiologically related. We conducted a nested case –control study (2009–2013) using incident sarcoidosis cases from the Swedish ...
Source: European Journal of Epidemiology - Category: Epidemiology Source Type: research
ConclusionA high proportion of patients clinically judged to have CS are unable to be classified according to the three main diagnostic criteria. There is low concordance between JCS criteria and the other two criteria (WASOG and HRS).
Source: American Heart Journal - Category: Cardiology Source Type: research
kal Lysozyme is a conserved antimicrobial enzyme and has been cited for its role in immune modulation. Increase in lysozyme concentration in body fluids is also regarded as an early warning of some diseases such as Alzheimer’s, sarcoidosis, Crohn’s disease, and breast cancer. Therefore, a method for a sensitive and selective detection of lysozyme can benefit many different areas of research. In this regard, several aptamers that are specific to lysozyme have been developed, but there is still a lack of a detection method that is sensitive, specific, and quantitative. In this work, we demonstrated a ...
Source: Sensors - Category: Biotechnology Authors: Tags: Article Source Type: research
Sarcoidosis is a systemic disease of unknown etiology characterized by the formation of granulomas in various organs [1]. T helper type 1 (Th1) responses and the Th1-associated cytokines have crucial roles in the pathogenesis of sarcoidosis. Recently, increased Th17 production and interleukin-17 (IL-17) positive cellular infiltration were reported [2]. Although the role of Th17 cells in the pathogenesis of sarcoidosis remains unclear, Th17 has been demonstrated to be important for promoting chronic inflammation in sarcoidosis and various autoimmune diseases [2,3].
Source: Journal of Dermatological Science - Category: Dermatology Authors: Source Type: research
Source: Journal of Nuclear Cardiology - Category: Nuclear Medicine Source Type: research
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