Biogen, Eisai's Alzheimer's Drug Succeeds in Mid-Stage Trial, Shares Soar Biogen, Eisai's Alzheimer's Drug Succeeds in Mid-Stage Trial, Shares Soar

Japanese drugmaker Eisai Co and Biogen Inc said that the final analysis of a mid-stage trial of their Alzheimer's drug showed positive results for patients who received the highest dose.Reuters Health Information
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Medscape Today News Source Type: news

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Publication date: Available online 21 July 2018Source: Chemico-Biological InteractionsAuthor(s): Bharath Kumar VelmuruganAbstractThe psychoactive properties of cannabinoids are well known and there has been a continuous controversy regarding the usage of these compounds for therapeutic purposes all over the world. Their use for medical and research purposes are restricted in various countries. However, their utility as medications should not be overshadowed by their negative physiological activities. This review article is focused on the therapeutic potential and applications of phytocannabinoids and endocannabinoids. It h...
Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research
Publication date: Available online 21 July 2018Source: Alzheimer's &DementiaAuthor(s):
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
Publication date: Available online 21 July 2018Source: Brain, Behavior, and ImmunityAuthor(s): Steffen E. Storck, Anika M.S. Hartz, Jessica Bernard, Andrea Wolf, André Kachlmeier, Anne Mahringer, Sascha Weggen, Jens Pahnke, Claus U. PietrzikAbstractThe accumulation of neurotoxic amyloid-beta (Aβ) in the brain is a characteristic hallmark of Alzheimer's disease (AD). The blood-brain barrier (BBB) provides a large surface area and has been shown to be an important mediator for removal of brain Aβ. Both, the ABC transporter P-glycoprotein (ABCB1/P-gp) and the receptor low-density lipoprotein receptor-related ...
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research
In conclusion, 4-PSQ protected against learning and memory impairment and anxiety in a mouse model of AD induced by Aβ, and anticholinesterase and antioxidant actions are involved in the pharmacological effect of the compound. PMID: 30021335 [PubMed - in process]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - Category: Drugs & Pharmacology Authors: Tags: Biomed Pharmacother Source Type: research
CONCLUSIONS: These findings indicated that applying the population-specific brain atlas to neuroimaging studies may achieve higher accuracy in activation detection. This may have implications to the imaging study of neurodegenerative diseases. PMID: 30024411 [PubMed - as supplied by publisher]
Source: Alzheimer Disease and Associated Disorders - Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research
This study aimed to evaluate the effects of sevoflurane on working memory of rats and to characterize functional connectivity between excitatory neurons in the prefrontal cortex (PFC) during working memory performance.Methods18-month-old and 3-month-old male SD rats were implanted with a multielectrode array in the PFC. After recovery from the surgery, the aged and adult rats were divided into sevoflurane group and control group, respectively. Rats in sevoflurane group were exposed to 1 minimum alveolar concentration (MAC) or 1.5 MAC sevoflurane for two hours. At day1, 3, and 7 after exposure, the effects of sevoflurane an...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
MULTI-TASK SPARSE SCREENING FOR PREDICTING FUTURE CLINICAL SCORES USING LONGITUDINAL CORTICAL THICKNESS MEASURES. Proc IEEE Int Symp Biomed Imaging. 2018 Apr;2018:1406-1410 Authors: Zhang J, Tu Y, Li Q, Caselli RJ, Thompson PM, Ye J, Wang Y Abstract Cortical thickness estimation performed in-vivo via magnetic resonance imaging (MRI) is an effective measure of brain atrophy in preclinical individuals at high risk for Alzheimer's disease (AD). However, the high dimensionality of individual cortical thickness data coupled with small population samples make it challenging to perform cortical thickness feat...
Source: Proceedings - International Symposium on Biomedical Imaging - Category: Radiology Tags: Proc IEEE Int Symp Biomed Imaging Source Type: research
Publication date: Available online 20 July 2018Source: Biochimica et Biophysica Acta (BBA) - General SubjectsAuthor(s): Yu Zhang, Yudan Zhao, Zhuoyi Wang, Hao Gong, Liang Ma, Dongsheng Sun, Chen Yang, Yang Li, Biao Cheng, Robert B. Petersen, Fengchao Jiang, Gongping Liu, Kun HuangAbstractProtein misfolding and aggregation are associated with amyloidosis. The toxic aggregation of amyloid-β 1–42 (Aβ42) may disrupt cell membranes and lead to cell death and is thus regarded as a contributing factor in Alzheimer's disease (AD). 1,4-naphthoquinone (NQ) has been shown to exhibit strong anti-aggregation effects on ...
Source: Biochimica et Biophysica Acta (BBA) General Subjects - Category: Biochemistry Source Type: research
In this study, by crossing hAPP (human amyloid prec ursor protein)-J20 mice with a line of GFAP-TK mice, we found that astrocytes were activated specifically at an early stage of AD before the occurrence of amyloid plaques, while microglia were not affected by this crossing. Activation of astrocytes at the age of 3–5 months did not affect the prot eolytic processing of hAPP and amyloid plaque loads in the brains of hAPP-J20 mice. Our data suggest that early activation of astrocytes does not affect the deposition of amyloid β in an animal model of AD.
Source: Neuroscience Bulletin - Category: Neuroscience Source Type: research
AbstractData Mining in medicine is an emerging field of great importance to provide a prognosis and deeper understanding of disease classification, specifically in Mental Health areas. The main objective of this paper is to present a review of the existing research works in the literature, referring to the techniques and algorithms of Data Mining in Mental Health, specifically in the most prevalent diseases such as: Dementia, Alzheimer, Schizophrenia and Depression. Academic databases that were used to perform the searches are Google Scholar, IEEE Xplore, PubMed, Science Direct, Scopus and Web of Science, taking into accou...
Source: Journal of Medical Systems - Category: Information Technology Source Type: research
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