Biogen, Eisai's Alzheimer's Drug Succeeds in Mid-Stage Trial, Shares Soar Biogen, Eisai's Alzheimer's Drug Succeeds in Mid-Stage Trial, Shares Soar

Japanese drugmaker Eisai Co and Biogen Inc said that the final analysis of a mid-stage trial of their Alzheimer's drug showed positive results for patients who received the highest dose.Reuters Health Information
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Medscape Today News Source Type: news

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Publication date: Available online 14 November 2018Source: Computational and Structural Biotechnology JournalAuthor(s): Jin-Lan Huang, Zhe-Hao Xu, Si-Man Yang, Chao Yu, Fan Zhang, Mei-Chun Qin, Yan Zhou, Zhen-Guo Zhong, Deng-Pan WuAbstractCircular RNAs (circRNAs) play vital roles in AD pathogenesis. Thus, developing therapeutic candidates targeting circRNA may provide a novel therapeutic strategy for AD treatment. Our previous studies showed that Panax notoginseng saponins (PNS) could significantly prohibit the pathological progress of AD. However, the mechanisms by which PNS attenuates AD progression is still unclear. The...
Source: Computational and Structural Biotechnology Journal - Category: Biotechnology Source Type: research
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB02319K, PaperPei-Qian Wu, Yi-Fan Yu, Ye Zhao, Chun-Xue Yu, De-Juan Zhi, Feng-Ming Qi, Dong-Qing Fei, Zhan-Xin Zhang Nardochinins A –D (1 –4), four novel sesquiterpenoids, were isolated fromNardostachys chinensis. Nardochinin B (2) can significantly inhibit the Alzheimer's disease (AD) like symptom of worm paralysis. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - Category: Molecular Biology Authors: Source Type: research
Publication date: Available online 12 November 2018Source: Biomedical Signal Processing and ControlAuthor(s): Salim Lahmiri, Amir ShmuelAbstractEarly detection of Alzheimer’s disease (AD) using structural magnetic resonance images is essential for early treatment that can slow the progression of the disease. Therefore, there is a need for accurate computer-aided-diagnosis (CAD) systems for detecting AD. The purpose of this work is to evaluate the degree to which specific features - including fractals obtained from MRI-based surfaces of the cerebral cortex, cortical thickness, gyrification index and the Alzheimer's di...
Source: Biomedical Signal Processing and Control - Category: Biomedical Science Source Type: research
Conditions:   Alzheimer's Disease;   Mild Cognitive Impairment Interventions:   Drug: MK-4334;   Drug: Placebo to MK-4334;   Drug: Donepezil Sponsor:   Merck Sharp & Dohme Corp. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Alzheimer Disease Intervention:   Device: Blood Brain Barrier (BBB) Disruption Sponsors:   InSightec;   Focused Ultrasound Foundation Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
We describe a novel clinical methodology used to evaluate and treat patients at two Alzheimer's Prevention Clinics. The framework applies evidence-based principles of clinical precision medicine to tailor individualized recommendations, follow patients longitudinally to continually refine the interventions, and evaluate N-of-1 effectiveness (trial registered at ClinicalTrials.gov NCT03687710). Prior preliminary results suggest that the clinical practice of AD risk reduction is feasible, with measurable improvements in cognition and biomarkers of AD risk. We propose using these early findings as a foundation to evaluate the...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
Publication date: Available online 12 November 2018Source: Alzheimer's &DementiaAuthor(s): Ketil Oppedal, Daniel Ferreira, Lena Cavallin, Afina W. Lemstra, Mara ten Kate, Alessandro Padovani, Irena Rektorova, Laura Bonanni, Lars-Olof Wahlund, Knut Engedal, Flavio Nobili, Milica Kramberger, John-Paul Taylor, Jakub Hort, Jon Snædal, Frederic Blanc, Zuzana Walker, Angelo Antonini, Eric Westman, Dag AarslandAbstractIntroductionWe explored regional brain atrophy patterns and their clinical correlates in dementia with Lewy bodies (DLB).MethodsIn this multicentre study, we included a total of 333 patients with DLB, 352 ...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
Publication date: Available online 12 November 2018Source: Pharmacology &TherapeuticsAuthor(s): Yu Chen, Amy K.Y. Fu, Nancy Y. IpAbstractAlzheimer's disease (AD), the most prevalent neurodegenerative disease in the elderly population, is characterized by progressive cognitive decline and pathological hallmarks of amyloid plaques and neurofibrillary tangles. However, its pathophysiological mechanisms are poorly understood, and diagnostic tools and interventions are limited. Here, we review recent research on the amyloid hypothesis and beta-amyloid–induced dysfunction of neuronal synapses through distinct cell surf...
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
More and more research supports the theory that Alzheimer disease, at least in some cases, may be caused by an early-life infection.Medscape Neurology
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Neurology & Neurosurgery Article Source Type: news
Klotho is one of a number of well-known longevity-associated genes. The amount of klotho observed in tissues declines steadily with advancing age. Interventions that increase levels of klotho have been shown to slow measures of aging to some degree in animal studies. Beyond life span, klotho is also strongly associated with cognitive function. More klotho is better in this case as well. Artificially raised levels of klotho might one day be used as a form of enhancement therapy, capable of improving cognitive function even in younger people. In the research noted here, scientists uncover one of the mechanisms linking...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
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