Sleep Apnea Linked to Changes in the Brain in Older Adults

MONDAY, July 9, 2018 -- Obstructive sleep apnea (OSA) is associated with changes to the structure of the brain that are seen in the early stages of dementia, according to a study published online July 5 in the European Respiratory Journal. Nathan E....
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news

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Abstract INTRODUCTION: The purpose of this investigation was to elucidate whether miR-125b targeting p38MAPK could relieve cognitive impairment of obstructive sleep apnea hypopnea syndrome (OSAHS) mice models. MATERIAL AND METHODS: The mice models were categorized into untreated control (UC), 10% continuous hypoxic (CH), 10% chronic intermittent hypoxia (CIH) and 5% chronic intermittent hypoxia (CIH) groups. Morris Water Maze, spatial navigation test and spatial probe test were conducted to appraise the learning, memorizing and cognitive abilities of mice models. Moreover, miR-125b and p38MAPK expressions wer...
Source: Current Neurovascular Research - Category: Neurology Authors: Tags: Curr Neurovasc Res Source Type: research
“To die, to sleep — perchance to dream — ay, there’s the rub, for in this sleep of death what dreams may come…” – William Shakespeare, Hamlet Everyone requires sleep in order to function properly. Sleep is known to aid in healing, in memory formation, reducing stress, eliminating toxins – literally wiping the slate clean of the day’s experiences to begin anew. The subject of decades of research, sleep science continues to amass evidence of new health benefits from sleep. A Single Gene Ties Sleep to Immunity A newly discovered single gene, called nemuri, increase...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Agitation Anger Memory and Perception Psychology Research Sleep Anger Management Circadian Rhythm Immune Function Insomnia nemuri nightmare disorder Nightmares Sleep Apnea Sleep Disorder sleep quality Source Type: blogs
By Sandee LaMotte, CNN (CNN) — Here’s another reason why getting a good night’s sleep should be on your must-do list: Sleeping fewer than six hours a night or waking frequently raises your risk of developing damaging plaque in arteries throughout your body, not just your heart. Previous research has shown poor sleep to be strongly associated with coronary heart disease, but “This is the first study to show that objectively measured sleep is independently associated with atherosclerosis throughout the body,” José Ordovás, director of nutrition and genomics at the Jean Mayer USDA H...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Health CNN Heart Disease Sleep Tufts University Source Type: news
Purpose of review Obstructive sleep apnea (OSA) is increasing in prevalence. The intermittent hypoxia of OSA has wide-ranging effects on a patient's general health outcomes. However, gold-standard investigations and treatment are expensive and a significant burden on patients. Therefore, OSA research remains focused on improving the means of diagnosing and treating OSA, in high-risk-associated conditions. This review is to provide an update on the advances in the field of OSA. Recent findings There has been recent debate about the best practice for diagnosis and treatment of OSA. Further work has been done on conditio...
Source: Current Opinion in Neurology - Category: Neurology Tags: NEURO-OPHTHALMOLOGY: Edited by Valérie Biousse Source Type: research
Publication date: Available online 7 December 2018Source: NeuroscienceAuthor(s): Teresa Macheda, Kelly Roberts, Danielle N Lyons, Emma Higgins, Kyle J Ritter, Ai-ling Lin, Warren J. Alilain, Adam D. BachstetterAbstractSleep disturbances are a common early symptom of neurodegenerative diseases, including Alzheimer’s disease (AD) and other age-related dementias, and emerging evidence suggests that poor sleep may be an important contributor to development of amyloid pathology. Of the causes of sleep disturbances, it is estimated that 10% - 20% of adults in the United States have sleep-disordered breathing (SDB) disorder...
Source: Neuroscience - Category: Neuroscience Source Type: research
The Go2Sleep Home Sleep Test is a revolutionary device on monitoring and improving your sleep quality. It elevates comfort while maintaining almost the same detecting accuracy of a pulse oximeter, but with a lot more key information. The precise data...
Source: Medgadget - Category: Medical Devices Authors: Tags: Sponsored Content Source Type: blogs
Conclusions:Uvulopalatopharyngoplasty may have a preventive effect on dementia in patients with OSA.Citation:Cho JH, Suh JD, Han KD, Jung JH, Lee HM. Uvulopalatopharyngoplasty may reduce the incidence of dementia caused by obstructive sleep apnea: National Insurance Service Survey 2007–2014.J Clin Sleep Med. 2018;14(10):1749–1755.
Source: Journal of Clinical Sleep Medicine : JCSM - Category: Sleep Medicine Source Type: research
The risk continues beyond the first years that obstructive sleep apnea is diagnosed Related items fromOnMedica Obstructive sleep apnoea Sleep apnoea might increase risk of atrial fibrillation Sleep apnoea in expectant mothers presents risk to newborns Could supplemental oxygen help sleep apnoea patients? Sleep disorder linked to brain changes indicative of dementia
Source: OnMedica Latest News - Category: UK Health Source Type: news
We present how new discoveries from animal models, human sleep experiments, and Alzheimer's disease biomarkers point to an active role of disturbed sleep in dementia pathogenesis. We show preliminary data on how sex, genetics, physical exercise and cognitive reserve can strengthen or weaken the association between obstructive sleep apnea and dementia. We present preliminary results of obstructive sleep apnea treatment, which can slow, stop or reverse neurodegenerative processes accentuated by obstructive sleep apnea, even in individuals already affected by a neurodegenerative disease. We propose future research directions ...
Source: American Journal of Respiratory and Critical Care Medicine - Category: Respiratory Medicine Authors: Tags: Am J Respir Crit Care Med Source Type: research
Epidemiologic and mechanistic evidence is increasingly supporting the notion that obstructive sleep apnea is a risk factor for dementia. Hence, the identification of patients at risk of cognitive decline due to obstructive sleep apnea may significantly improve preventive strategies and treatment decision-making. Cerebrospinal fluid and blood biomarkers obtained through genomic, proteomic and metabolomic approaches are improving the ability to predict incident dementia. Therefore, fluid biomarkers have the potential to predict vulnerability to neurodegeneration in individuals with obstructive sleep apnea, as well as deepen ...
Source: Sleep Medicine Reviews - Category: Sleep Medicine Authors: Tags: Clinical Review Source Type: research
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