Use of Hydroxocobalamin (Vitamin B12a) in Patients With Vasopressor Refractory Hypotension After Cardiopulmonary Bypass: A Case Series.

Use of Hydroxocobalamin (Vitamin B12a) in Patients With Vasopressor Refractory Hypotension After Cardiopulmonary Bypass: A Case Series.
Anesth Analg. 2018 Jul 02;:
Authors: Armour S, Armour TK, Joppa WR, Maltais S, Nelson JA, Wittwer E
Abstract
Hydroxocobalamin (vitamin B12a) is an emerging treatment for vasoplegic syndrome (VS) associated with cardiopulmonary bypass (CPB). Given its cost and scarcity, an institutional guideline for its use as a rescue treatment in cases of suspected VS was developed. Hemodynamic variables and vasopressor requirements were reviewed for a series of 24 post-CPB patients who received B12a. Favorable changes in hemodynamic parameters and vasopressor requirements were seen after B12a administration although guideline criteria for VS were inconsistently met. These findings support the continued study of B12a in patients with CPB-associated VS.
PMID: 29979199 [PubMed - as supplied by publisher]

Source: Anesthesia and Analgesia - July 2, 2018 Category: Anesthesiology Authors: Armour S, Armour TK, Joppa WR, Maltais S, Nelson JA, Wittwer E Tags: Anesth Analg Source Type: research