Clinical application and technical considerations of T1 & T2(*) mapping in cardiac, liver, and renal imaging.

Clinical application and technical considerations of T1 & T2(*) mapping in cardiac, liver, and renal imaging. Br J Radiol. 2018 Jul 05;:20180825 Authors: Dekkers IA, Lamb HJ Abstract Pathological tissue alterations due to disease processes such as fibrosis, edema and infiltrative disease can be non-invasively visualized and quantified by magnetic resonance imaging using T1 and T2 relaxation properties. Pixel-wise mapping of T1 and T2 image sequences enable direct quantification of T1, T2(*), and extra-cellular volume (ECV) values of the target organ of interest. Tissue characterization based on T1 and T2(*) mapping is currently making the transition from a research tool to a clinical modality, as clinical usefulness has been established for several diseases such as myocarditis, amyloidosis, Anderson-Fabry and iron deposition,. Other potential clinical applications besides the heart include, quantification of steatosis, cirrhosis, hepatic siderosis and renal fibrosis. Here, we provide an overview of potential clinical applications of T1, T2(*) mapping for imaging of cardiac, liver and renal disease. Furthermore, we give an overview of important technical considerations necessary for clinical implementation of quantitative parametric imaging, involving data acquisition, data analysis, quality assessment, and interpretation. In order to achieve clinical implementation of these techniques, standardization of T1 and T2(*) mapping meth...
Source: The British Journal of Radiology - Category: Radiology Authors: Tags: Br J Radiol Source Type: research