Heterozygous CDKL5 Knockout Female Mice Are a Valuable Animal Model for CDKL5 Disorder.

In conclusion, our study provides a comprehensive overview of neurobehavioral phenotypes of heterozygous female Cdkl5 +/- mice and demonstrates that the heterozygous female might be a valuable animal model in preclinical studies on CDKL5 disorder.
PMID: 29977282 [PubMed - in process]

Source: Neural Plasticity - July 7, 2018 Category: Neurology Authors: Fuchs C, Gennaccaro L, Trazzi S, Bastianini S, Bettini S, Martire VL, Ren E, Medici G, Zoccoli G, Rimondini R, Ciani E Tags: Neural Plast Source Type: research