Cystic Fibrosis

Title: Cystic FibrosisCategory: Diseases and ConditionsCreated: 12/31/1997 12:00:00 AMLast Editorial Review: 7/6/2018 12:00:00 AM
Source: MedicineNet Lungs General - Category: Respiratory Medicine Source Type: news

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This study describes the peer bullying experiences of young people with CF, and examines associations between school bullying and the psychological well-being of these young people. A sequential mixed-methods approach was used to collect data from 26 young people with CF (10-16 years of age). These data were compared with large samples of healthy children. Following an online survey, 11 young people, through online focus groups, expanded on the survey findings, describing their experiences within the school environment. Young people with CF reported lower involvement in bullying victimization and perpetration relative to t...
Source: The American Journal of Orthopsychiatry - Category: Psychiatry Tags: Am J Orthopsychiatry Source Type: research
Conclusions: Genetic mutations leading to impaired host-defense might have implicated in the pathogenesis of bronchiectasis. Genetic screening may be a useful tool for unraveling the underlying causes of bronchiectasis, and offers molecular information which is complementary to conventional etiologic assessment for bronchiectasis. PMID: 29997923 [PubMed]
Source: Journal of Thoracic Disease - Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research
The severity of intestinal disease associated with Cystic Fibrosis (CF) is variable in the patient population and this variability is partially conferred by the influence of modifier genes. Genome-wide association studies have identifiedSLC6A14, an electrogenic amino acid transporter, as a genetic modifier of CF-associated meconium ileus. The purpose of the current work was to determine the biological role ofSlc6a14, by disrupting its expression in CF mice bearing the major mutation, F508del. We found that disruption ofSlc6a14 worsened the intestinal fluid secretion defect characteristic of these mice.In vitro studies of m...
Source: eLife - Category: Biomedical Science Tags: Human Biology and Medicine Source Type: research
This draft guidance sets out an antimicrobial prescribing strategy for managing and preventing an acute exacerbation of bronchiectasis (non-cystic fibrosis). It aims to optimise antibiotic use and reduce antibiotic resistance. A 3-page visual summary of the recommendations is included.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
Abstract Air-liquid interface culture enables airway epithelial cells to differentiate into a pseudostratified cell layer, consisting of ciliated cells, goblet/secretory cells, and basal cells (Ghio et al., Part Fibre Toxicol 10:25, 2013). This technique is critically important for in vitro studies of lung diseases such as asthma, chronic obstructive pulmonary disease, and cystic fibrosis, since differentiated airway epithelial cells are more representative of the in vivo lung environment than non-differentiated cells (Derichs et al., FASEB J 25:2325-2332, 2011; Hackett et al., Am J Respir Cell Mol Biol 45:1090-11...
Source: Respiratory Care - Category: Respiratory Medicine Authors: Tags: Methods Mol Biol Source Type: research
Pediatric Pulmonology, EarlyView.
Source: Pediatric Pulmonology - Category: Respiratory Medicine Authors: Source Type: research
Conclusions: The mean cost of a hospitalization due to bronchiectasis exacerbation obtained from the individual data of each episode is higher than the cost per process calculated by the health authorities. The most determining factor of a higher cost is chronic bronchial infection due toP. aeruginosa, which leads to a longer hospital stay and the use of home hospitalization.Respiration
Source: Respiration - Category: Respiratory Medicine Source Type: research
Publication date: February 2018Source: Journal of Applied Biomedicine, Volume 16, Issue 1Author(s): Lucia Lauková, Barbora KonečnáAbstractNeutrophils play an important role as the central mediators of the innate immune defence response, providing the first line of host protection. It was shown that these cells can trap and kill various microorganisms through different ways. One of them is a release of neutrophil extracellular traps (NETs) composed of chromatin fibrils and antimicrobial proteins. There is the evidence that the release of NETs does not have only a beneficial effect. NETs can trap and kill micr...
Source: Journal of Applied Biomedicine - Category: Biotechnology Source Type: research
Publication date: 1 May 2018Source: Methods, Volumes 140–141Author(s): Elvis Pandžić, Asmahan Abu-Arish, Renee M. Whan, John W. Hanrahan, Paul W. WisemanAbstractMolecular, vesicular and organellar flows are of fundamental importance for the delivery of nutrients and essential components used in cellular functions such as motility and division. With recent advances in fluorescence/super-resolution microscopy modalities we can resolve the movements of these objects at higher spatio-temporal resolutions and with better sensitivity. Previously, spatio-temporal image correlation spectroscopy has been applied to map mole...
Source: Methods - Category: Molecular Biology Source Type: research
Publication date: September 2018Source: Redox Biology, Volume 18Author(s): Chiang-Wen Lee, Cheng-Hsun Wu, Yao-Chang Chiang, Yuh-Lien Chen, Kuo-Ting Chang, Chu-Chun Chuang, I-Ta LeeAbstractPseudomonas aeruginosa (P. aeruginosa) infection in the lung is common in patients with cystic fibrosis (CF). Intercellular adhesion molecule-1 (ICAM-1) is known to play a key role in lung inflammation. Acute inflammation and its timely resolution are important to ensure bacterial clearance and limit tissue damage. Carbon monoxide (CO) has been shown to exert anti-inflammatory effects in various tissues and organ systems. Here, we explore...
Source: Redox Biology - Category: Biology Source Type: research
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