Cell cycle-related kinase mediates viral-host signalling to promote hepatitis B virus-associated hepatocarcinogenesis

Conclusions
Our findings highlight the critical role of CCRK in a self-reinforcing circuitry that regulates HBV-associated hepatocarcinogenesis. Further characterisation of this intricate viral-host signalling may provide new prognostic biomarkers and therapeutic targets for HCC treatment.

Source: Gut - October 2, 2014 Category: Gastroenterology Authors: Yu, Z., Gao, Y.-Q., Feng, H., Lee, Y.-Y., Li, M. S., Tian, Y., Go, M. Y. Y., Yu, D.-Y., Cheung, Y.-S., Lai, P. B. S., Yu, J., Wong, V. W. S., Sung, J. J. Y., Chan, H. L. Y., Cheng, A. S. L. Tags: Hepatic cancer Hepatology Source Type: research