GSE108061 Drug sensitivity screening and genomic characterization of 45 HPV-negative head and neck carcinoma cell lines for novel biomarkers of drug efficacy [gene expression]

Contributors : Tatiana Lepikhova ; Piia-Riitta Karhemo ; Riku Louhimo ; Bhagwan Yadav ; Astrid Murum ägi ; Evgeny Kulesskiy ; Mikko Kivento ; Harri Sihto ; Reidar Grenman ; Stina Syrjänen ; Olli Kallioniemi ; Tero Aittokallio ; Krister Wennerberg ; Heikki Joensuu ; Outi MonniSeries Type : Expression profiling by arrayOrganism : Homo sapiensThere is an unmet need for effective targeted therapies for patients with advanced head and neck squamous cell carcinoma (HNSCC). We correlated gene expression, gene copy numbers and point mutations in 45 human papillomavirus negative HNSCC cell lines with the drug sensitivity to 220 anticancer agents to discover predictive biomarkers. The drug response profiles revealed diverse efficacy of the tested drugs across the cell lines. Several genomic abnormalities and gene expression differences were associated with response to mTOR, MEK and EGFR inhibitors. NOTCH1 and NAV3 mutations were associated with response to MEK and EGFR inhibitors. MYC amplification and FAM83H overexpression were associated with sensitivity to EGFR inhibitors, and PTPRD deletion with poor sensitivity to MEK inhibitors. The novel link between high FAM83H expression and responsiveness to the EGFR inhibitor erlotinib was validated by using the Cancer Cell Line Encyclopedia. The data provide several novel predictive biomarkers to targeted drugs in HNSCC. These biomarkers require further validation in clinical series.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research