Sesquiterpenoids from Ainsliaea yunnanensis and their cytotoxic activities

Publication date: August 2018Source: Phytochemistry Letters, Volume 26Author(s): Xin Fang, Ren-Tao Zeng, Zhi-Guo Zhuo, Yun-Heng Shen, Wei-Dong ZhangAbstractThree new sesquiterpenoids, named yunnanolides J-K and yunnanol A (1-3), together with ten known sesquiterpenoids (4-13), have been isolated from the dried whole plants of Ainsliaea yunnanensis Franch. The chemical structures of compounds 1-3 were elucidated by NMR and HRESIMS analysis. All the compounds were tested for in vitro cytotoxicity against three human tumor cell lines (95D, MDA-MB-231, and HepG2). Compound 13 showed moderate cytotoxicity against human cancer cell lines MDA-MB-231 (IC50 = 18.2 μM) and HepG2 (IC50 = 12.2 μM), respectively.Graphical abstractThree new sesquiterpenoids (1-3) and ten known ones (4-13) were isolated from the dried whole plants of Ainsliaea yunnanensis Franch. The chemical structures of three new sesquiterpenoids were elucidated by 1D, 2D NMR and MS techniques. All compounds were evaluated for cytotoxicity against three human tumor cell lines 95D, MDA-MB-231, and HepG2.
Source: Phytochemistry Letters - Category: Chemistry Source Type: research