New anti-glycative flavonoids from Cirsium setidens with potent radical scavenging activities

Publication date: August 2018Source: Phytochemistry Letters, Volume 26Author(s): Gyeong Han Jeong, Eui Kyun Park, Tae Hoon KimAbstractTwo new methoxylated flavonoids, setidenosides A (1) and B (2), together with three known constituents, linarin (3), 5-O-E-p-coumarolyquinic acid methyl ester (4), and syringin (5), were isolated from a methanol extract of the aerial parts of Cirsium setidens Nakai (Asteraceae) through bioassay-guided fractionation using advanced glycation end products (AGEs) formation assay. The structures of the new compounds were elucidated by spectroscopic and chemical methods Among these isolated compounds, new compounds 1 and 2 showed significant inhibitory effects on AGEs formation with IC50 values of 6.5 ± 0.2 and 9.7 ± 0.3 μM, respectively. In addition, these two new compounds showed significant radical scavenging capacities in an ONOO− scavenging assay.Graphical abstract

Source: Phytochemistry Letters - July 6, 2018 Category: Chemistry Source Type: research