Leptothiazinones A and B, two new Benzothiazinones from a marine-derived fungus Leptosphaerulina chartarum 3608

Publication date: October 2018Source: Phytochemistry Letters, Volume 27Author(s): Panpan Zhang, Chunxiu Jia, Jiajia Lang, Hongjie Shen, Jing Li, Senhua Chen, Lan LiuAbstractTwo new benzothiazinones, namely leptothiazinones A and B (1 and 2) were isolated from the marine-derived fungus Leptosphaerulina chartarum 3608. The structures of compounds 1 and 2 were elucidated by extensive spectroscopic analysis, including HR-ESIMS, 1D and 2D NMR, and single-crystal X-ray diffraction analysis. Leptothiazinone B possessing a benzo[b][1,4]thiazin-2-one skeleton was first reported in natural sources. Both of them were tested for their cytotoxicity, antibacterial, and anti-inflammatory activities.Graphical abstract

Source: Phytochemistry Letters - July 6, 2018 Category: Chemistry Source Type: research