Modeling and comparison of alternative approaches for sector duration optimization in a dedicated radiosurgery system.

Modeling and comparison of alternative approaches for sector duration optimization in a dedicated radiosurgery system. Phys Med Biol. 2018 Jul 04;: Authors: Cevik M, Shirvani Ghomi P, Aleman DM, Lee Y, Berdyshev A, Nordstrom H, Riad S, Sahgal A, Ruschin M Abstract Stereotactic radiosurgery (SRS) is an effective technique to treat brain metastasis for which several inverse planning methods may be appropriate. We compare three different models for segment duration optimization in SRS using Leksell Gamma Knife{\textregistered} Icon{\texttrademark} (Elekta, Stockholm, Sweden). We investigate (1) a linear programming approach, (2) a piecewise quadratic penalty approach, and (3) an unconstrained convex moment-based penalty approach. The performance of these approaches is assessed using anonymized data from 14 previously treated cases. The treatment plans obtained via optimization models are compared against each other and against the clinical plans. Several benchmarks are compared, with the goal to evaluate the effectiveness of each model in terms of generating an initial plan that satisfies specified requirements. The three inverse planning models can all obtain optimal treatment plans in a reasonable amount of time. We observe that the treatment plans obtained by these models meet or exceed clinical guidelines while displaying high conformity. PMID: 29972141 [PubMed - as supplied by publisher]
Source: Physics in Medicine and Biology - Category: Physics Authors: Tags: Phys Med Biol Source Type: research