Summaries: International Kidney Cancer Symposium

Conclusion: there is no increased risk of doing the lymph node dissection early on. Dr. Eggener-CON  Basics Lymph node dissections rarely done, even for large tumors, because there is no proven therapeutic or staging benefit for low risk patients.  A Mayo study revealed no data showing therapeutic benefit in high risk patients.  For clinically node negative high risk patients, there is staging value but no proven therapeutic benefit. Rate of positive nodes is associated with stage and grade; the higher the stage and grade, the more likely there will be positive nodes.  A tumor> 10 cm with sarcomatoid features and tumor necrosis is also associated with positive nodes. Looking at several studies, the percentage of patients that were found to have positive nodes at the time of surgery was relatively small in all but one study.  The 5-year cancer specific survival for these patients was very consistent at 35-39%. According to the National Comprehensive Cancer Network guidelines for kidney cancer,“Regional lymph node dissection is optional but is recommended for patients with adenopathy on preoperative imaging or palpable/visible adenopathy at time of surgery.” Conclusions: Lymph node dissection for patients with clinical node negative T1-T2 disease is proven not to be necessary Lymph node dissection for patients with clinical node negative T3-T4 disease is reasonable but of unproven therapeutic benefit L...
Source: Kidney Cancer Association - Category: Urology & Nephrology Source Type: news

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In this study, we found that TLR1/TLR2 expression predicted favorable prognosis of lung cancer patients. In the related mice tumor model, TLR1/TLR2 activation by synthetic bacterial lipoprotein (BLP), a TLR1/2 agonist, greatly inhibited tumor growth and selectively decreased monocytic MDSCs (M-MDSCs). Furthermore, BLP treatment redirected M-MDSC differentiation towards M1 macrophage through JNK pathway, and thus blocked the suppressive activity of M-MDSCs in a TLR2-dependent manner. Therefore, our data demonstrated that TLR2 could be a promising biomarker and a potential immunotherapeutic target for lung cancer.
Source: Molecular Immunology - Category: Allergy & Immunology Source Type: research
Publication date: August 2019Source: Molecular Immunology, Volume 112Author(s): Elizabeth A. Bemis, Jill M. Norris, Jennifer Seifert, Ashley Frazer-Abel, Yuko Okamoto, Marie L. Feser, M. Kristen Demoruelle, Kevin D. Deane, Nirmal K. Banda, V. Michael HolersAbstractRheumatoid arthritis (RA) is a complex autoimmune disease with an etiology that is not yet well understood, disproportionally affects women and also varies in incidence and prevalence by population. The presence of anti-citrullinated protein antibodies (ACPA) is a highly specific biomarker for the diagnosis of clinically apparent RA. ACPA are also present in the ...
Source: Molecular Immunology - Category: Allergy & Immunology Source Type: research
CONCLUSIONS: These data provide the current PCI practice pattern with the use of FFR and IVUS in intermediate lesion. More common use of FFR for intermediate lesion should be encouraged. PMID: 31190480 [PubMed - as supplied by publisher]
Source: Korean Circulation Journal - Category: Cardiology Tags: Korean Circ J Source Type: research
CONCLUSIONS: Separate examination of control rates demonstrated different sex- and age-differential trends, which would have been overlooked in combined control rates. PMID: 31190479 [PubMed - as supplied by publisher]
Source: Korean Circulation Journal - Category: Cardiology Tags: Korean Circ J Source Type: research
Publication date: Available online 15 June 2019Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Yang Xiong, Ying Wang, Karthik TiruthaniAbstractColorectal cancer (CRC) is predicted to be the 2nd leading cause of cancer-related death in United States in 2019. Immunotherapies such as checkpoint inhibitors have proven efficacy in patients with high level of microsatellite instability and refractory to routine chemotherapy. Despite this, immunotherapy-based treatment is seriously limited by cancer immunogenicity which are evolved to evade immune surveillance in many circumstances. Efforts are made by resear...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - Category: Nanotechnology Source Type: research
Publication date: Available online 15 June 2019Source: Nano TodayAuthor(s): Weijing Yang, Zijian Zhou, Joseph Lau, Shuo Hu, Xiaoyuan ChenAbstractImmunotherapy (e.g., checkpoint blockade, adoptive T cell therapy, cancer vaccine) has emerged as one of the most important treatment modalities for cancer in the past two decades. While these approaches are promising, the response rates observed in clinical trials are less than 30% due to tumor heterogeneity and complexity of the tumor microenvironment. Smart nanosystems have the potential to address some of the limitations associated with immunotherapy. Herein, we review applica...
Source: Nano Today - Category: Nanotechnology Source Type: research
Publication date: 2019Source: Materials Today: Proceedings, Volume 15, Part 2Author(s): Sumit Das Lala, Payel Deb, Emon Barua, Ashish.B. Deoghare, Sushovan ChatterjeeAbstractNano-sized Hydroxyapatite (HAp) powders are synthesized from natural bio-waste chicken eggshell. The synthesized powder is characterized using X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR) which confirms the formation of HAp. Scanning Electron Microscopy (SEM) shows highly porous agglomerated HAp powder with average pore diameter of 276.3 nm. EDAX analysis reveals calcium and phosphate ratio (Ca/P) of 1.74 showing close res...
Source: Materials Today: Proceedings - Category: Materials Science Source Type: research
ConclusionIn asthma management, All the inhalation drugs in combination show better control and superior patients response in the management of asthma with more impact on economic aspects of the patients.
Source: Materials Today: Proceedings - Category: Materials Science Source Type: research
Publication date: 2019Source: Materials Today: Proceedings, Volume 15, Part 2Author(s): M. Lickmichand, Crystal Sara Shaji, N. Valarmathi, Amy Sarah Benjamin, R.K. Arun Kumar, Sunita Nayak, Radha Saraswathy, S. Sumathi, N. Arunai Nambi RajAbstractThe magnetic cobalt ferrite nanoparticles (CoFe2O4) were synthesized by sol-gel combustion technique and encapsulated with polyethylene glycol (PEG). The phase formation and crystalline nature were confirmed by X-ray diffraction (XRD) and Fourier Transform Infrared Spectroscopy (FTIR). The microstructure and elemental composition were characterized using Scanning Electron Microsco...
Source: Materials Today: Proceedings - Category: Materials Science Source Type: research
Publication date: 2019Source: Materials Today: Proceedings, Volume 15, Part 2Author(s): G. Priya, R. Anitha, R. Akila, U. Narendra Kumar, I. ManjubalaAbstractFailure of implants is a serious concern in the orthopedic field, due to loosening of the parts or biofilm formation. This leads to secondary surgery increasing the cost for the patients. The analysis of the ability of the implants to be resistant to infection or susceptible to biofilm growth before implantation could minimize this issue. The aim of this study is to investigate the ability to form biofilm on composite scaffolds, made up of polymer and calcium phosphat...
Source: Materials Today: Proceedings - Category: Materials Science Source Type: research
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