Caregiver experience, health ‐related quality of life and life satisfaction among informal caregivers to patients with amyotrophic lateral sclerosis: a cross‐sectional study

Journal of Clinical Nursing,Volume 0, Issue ja, -Not available-.
Source: Journal of Clinical Nursing - Category: Nursing Authors: Source Type: research

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Journal of Proteome ResearchDOI: 10.1021/acs.jproteome.0c00216
Source: Journal of Proteome Research - Category: Biochemistry Authors: Source Type: research
Conclusions: HWE deviation of particular variants in relation to global populational HWE, could be, at least in part, associated with the differential susceptibility of specific populations and ethnicities to neurodegenerative diseases. Our data might contribute to the epidemiology and diagnostic/prognostic methods for neurodegenerative diseases.RESUMO Introdu ção: Mitocôndrias defeituosas ou danificadas resultam em alterações do metabolismo energético, equilíbrio redox e dinâmica celular e são, portanto, identificadas como o ponto central da patogênese em ...
Source: Arquivos de Neuro-Psiquiatria - Category: Neurology Source Type: research
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Source: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration - Category: Neurology Authors: Source Type: research
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Source: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration - Category: Neurology Authors: Source Type: research
AbstractHIV-associated neuroinflammation is primarily driven by CNS macrophages including microglia. Regulation of these immune responses, however, remains to be characterized in detail. Using the SIV/macaque model of HIV, we evaluated CNS expression of triggering receptor expressed on myeloid cells 2 (TREM2) which is constitutively expressed by microglia and contributes to cell survival, proliferation, and differentiation. Loss-of-function mutations in TREM2 are recognized risk factors for neurodegenerative diseases including Alzheimer ’s disease (AD), amyotrophic lateral sclerosis (ALS), and Nasu-Hakola disease (NH...
Source: Journal of NeuroVirology - Category: Neurology Source Type: research
Conclusions: As more states authorize medical cannabis use, there is an increasing need for high-quality clinical evidence describing its efficacy and safety. This review is intended to serve as a reference for clinicians, so that the risks and realistic benefits of medical cannabis are better understood. PMID: 32483988 [PubMed - as supplied by publisher]
Source: The Annals of Pharmacotherapy - Category: Drugs & Pharmacology Authors: Tags: Ann Pharmacother Source Type: research
Publication date: Available online 30 May 2020Source: NeuroImage: ClinicalAuthor(s): Rangariroyashe H. Chipika, Eoin Finegan, Stacey Li Hi Shing, Mary C. McKenna, Foteini Christidi, Kai Ming Chang, Mark A. Doherty, Jennifer C. Hengeveld, Alice Vajda, Niall Pender, Siobhan Hutchinson, Colette Donaghy, Russell L. McLaughlin, Orla Hardiman, Peter Bede
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
AbstractBackgroundAmyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that causes eventual death through respiratory failure unless mechanical ventilation is provided. Brain –machine interfaces (BMIs) may provide brain control supports for communication and motor function. We investigated the interests and expectations of patients with ALS concerning BMIs based on a large-scale anonymous questionnaire survey supported by the Japan Amyotrophic Lateral Sclerosis Associa tion.MethodsWe surveyed 1918 patients with ALS regarding their present status, tracheostomy use, interest in BMIs, and their...
Source: Journal of Neurology - Category: Neurology Source Type: research
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Source: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration - Category: Neurology Authors: Source Type: research
FUS is a nucleic acid binding protein that, when mutated, cause a subset of familial amyotrophic lateral sclerosis (ALS). Expression of FUS in yeast recapitulates several pathological features of the disease-causing mutant proteins, including nuclear to cytoplasmic translocation, formation of cytoplasmic inclusions, and cytotoxicity. Genetic screens using the yeast model of FUS have identified yeast genes and their corresponding human homologs suppressing FUS induced toxicity in yeast, neurons and animal models. To expand the search for human suppressor genes of FUS induced toxicity, we carried out a genome-scale genetic s...
Source: G3: Genes Genomes Genetics - Category: Genetics & Stem Cells Authors: Tags: Mutant Screen Report Source Type: research
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