Enhanced estrogenic effects of biotransformed soy extracts

This study aimed to improve the process conditions for biotransformation of soymilk polyphenols by tannase to obtain higher amounts of isoflavone aglycones and metabolites such as equol. The estrogenic potential of the extracts was evaluated in in vitro assays. The results showed that the aglycones increased 36–46 times after reaction with tannase and proved that it is possible to produce equol in soymilk using an enzymatic bioprocess, without gut microbial intervention. Moreover, the soymilk biotransformed by tannase presented higher estrogenic action in the MCF-7 BUS cell line assay, making it a promising nutraceutical with possible effects in the attenuation or treatment of menopause symptoms.Graphical abstract
Source: Journal of Functional Foods - Category: Nutrition Source Type: research

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Conclusions World population is aging and the increase in life expectancy is often unhealthy. In particular, musculoskeletal aging, which leads to sarcopenia and osteoporosis, has several causes such as changes in body composition, inflammation, and hormonal imbalance. Sarcopenia, osteoporosis, and more frequently, sarcopenic obesity are commonly associated with aging and frequently closely linked each other, often leading to the development of a frailty syndrome. Frailty syndrome favors an increased risk of loss function in daily activities, for cardiovascular diseases, cancers, falls, and mortality. As the number of eld...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
A brief course of acupuncture may help ease menopausal symptoms and offer a treatment alternative to hormone replacement therapy, suggested astudy in BMJ Open.
Source: JAMA - Category: General Medicine Source Type: research
A 49 year old surgically menopausal female on hormone replacement therapy presented to our clinic with persistent abdominal pain, pelvic pressure, nausea, and vomiting. She had history of severe endometriosis with prior total abdominal hysterectomy and bilateral salpingo-oophorectomy (BSO) performed at an outside facility. Significant bowel adhesions were encountered intra-operatively and the endometriosis was incompletely excised. A pelvic MRI at our institution demonstrated a nodular lesion in the sigmoid colon measuring 15  × 11mm impressing upon the wall of the colon resulting in luminal narrowing over a leng...
Source: The Journal of Minimally Invasive Gynecology - Category: OBGYN Authors: Tags: Original Article Source Type: research
(Reuters Health) - Women who take hormone replacement therapy (HRT) to ease menopause symptoms like hot flashes and night sweats may be slightly more likely to develop Alzheimer's disease, a large Finnish study suggests.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
Publication date: Available online 28 February 2019Source: Journal of Minimally Invasive GynecologyAuthor(s): Sadikah Behbehani, Tiffany Pham, Katie Kunze, Megan Wasson, Johnny YiABSTRACTStudy ObjectiveTo determine the incidence of a successful in-office voiding trial after minimally invasive hysterectomy.DesignA retrospective cohort study.SettingA tertiary care academic center.PatientsAll patients undergoing minimally invasive hysterectomies (vaginal, laparoscopic, or robotic) from January 2013 to July 2018 who have an unsuccessful voiding trial in the postoperative unit.InterventionsA voiding trial.Measurements and Main ...
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
An estimated one million women in Britain and five per cent of women over the age of 50 in the US take hormone replacement therapy to help relieve menopause symptoms.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
A small study shows that acupuncture is better than no treatment for menopausal symptoms and is a realistic option for women who cannot or do not wish to use hormone replacement therapy (HRT), say researchers.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Diabetes & Endocrinology News Source Type: news
Publication date: Available online 28 February 2019Source: Journal of Minimally Invasive GynecologyAuthor(s): Sadikah Behbehani, Tiffany Pham, Katie Kunze, Megan Wasson, Johnny YiAbstractStudy ObjectiveDetermine the incidence of successful in-office voiding trial after minimally invasive hysterectomy.DesignRetrospective cohort studySettingTertiary care academic centerPatients or ParticipantsAll patients undergoing minimally invasive hysterectomies (vaginal, laparoscopic, or robotic) from January 2013 to July 2018 who have unsuccessful voiding trial in the post-operative unitInterventionsVoiding trialMeasurements and Main R...
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
Abstract The prevalence of cardiometabolic syndrome (CMS) is increased in women after menopause. While hormone replacement therapy has been prescribed to relieve several components of CMS in postmenopausal women, some aspects of cardiometabolic dysfunction cannot be completely restored. The present study examined the effectiveness of estrogen replacement alone and in combination with exercise by voluntary wheel running (VWR) for alleviating the risks of CMS, insulin-mediated skeletal muscle glucose transport and hepatic fat accumulation in ovariectomized Sprague-Dawley rats fed a high-fat high-fructose diet (OHFFD...
Source: Am J Physiol Endocri... - Category: Endocrinology Authors: Tags: Am J Physiol Endocrinol Metab Source Type: research
ConclusionsIn this retrospective cohort of women with fecal incontinence, no clinical or manometric differences were observed between women who wore high heels versus those who did not. Because there is limited knowledge on this potential link and because the pelvic tilt may vary according to age and the habit of walking with high heels, further studies are necessary.
Source: International Urogynecology Journal - Category: OBGYN Source Type: research
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