Prolactin signaling drives tumorigenesis in human high grade serous ovarian cancer cells and in a spontaneous fallopian tube derived model

The pathways responsible for tumorigenesis of high grade serous ovarian cancer (HGSOC) from the fallopian tube epithelium (FTE) are still poorly understood. A human prolactin (PRL) like gene, Prl2c2 was amplified>100 fold in a spontaneous model of FTE-derived ovarian cancer (MOEhigh - murine oviductal epithelium high passage). Prl2c2 stable knockdown in MOEhigh cells demonstrated a significant reduction in cell proliferation, 2-dimensional foci, anchorage independent growth, and completely blocked tumor formation.

Source: Cancer Letters - July 5, 2018 Category: Cancer & Oncology Authors: Subbulakshmi Karthikeyan, Angela Russo, Matthew Dean, Daniel D. Lantvit, Michael Endsley, Joanna E. Burdette Tags: Original Articles Source Type: research