Introduction to Acquired and Inherited Bone Marrow Failure

Acquired aplastic anemia and inherited bone marrow failure syndromes both present with pancytopenia and must be distinguished because they have differences in treatment decisions and continued monitoring requirements. Advances in the genetic interrogation of patient samples have led to identification of inherited germline diseases and appreciation that patients with inherited bone marrow failure disorders may be normal in appearance with few expected clinical clues. Somatic mutations in aplastic anemia may have prognostic value. Hematopoietic stem cells from inherited marrow failure diseases can correct the proliferative defect and may develop further somatic mutations that progress to myelodysplastic syndrome or acute myeloid leukemia.
Source: Hematology/Oncology Clinics of North America - Category: Cancer & Oncology Authors: Source Type: research

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Source: Stem Cell Research - Category: Stem Cells Source Type: research
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Source: Life Sciences - Category: Biology Source Type: research
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Source: European Cells and Materials - Category: Cytology Tags: Eur Cell Mater Source Type: research
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Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Drosophila melanogaster Source Type: research
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Source: Critical Care Medicine - Category: Emergency Medicine Tags: Concise Definitive Review Source Type: research
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