Carob extract attenuates brain and lung injury in rats exposed to waterpipe smoke

Publication date: March 2018Source: Egyptian Journal of Basic and Applied Sciences, Volume 5, Issue 1Author(s): Mona Abdel-Rahman, Amira A. Bauomy, Fatma Elzahraa H. Salem, Mona Ahmed KhalifaAbstractWaterpipe smoking is one of the most popular methods of tobacco consumption world-wide which induces many health problems. In the present study; we evaluated the toxic effects of waterpipe smoke by using amiodarone as a model for lung toxicity in adult male albino rats. Also, the protective and therapeutic effects of carob aqueous extract on these toxicity which produced by daily exposure to waterpipe smoke for 8 weeks. The amiodarone gavage significantly increased serotonin content in brainstem and cerebral cortex after 8 and 2 weeks respectively and dopamine content at most of time intervals. Moreover, waterpipe smoke exposure induced a significant decrease in dopamine content after 2 weeks in brainstem and in serotonin content after 4, 6 weeks in brainstem and 6, 8 weeks in cerebral cortex. While, increment in dopamine content after 4, 6 weeks in brainstem and 6, 8 weeks in cerebral cortex may be due to increase its synthesis which strengthens the coughing reflex. Amiodarone gavage and waterpipe smoke exposure induced a significant increase in myeloperoxidase activity, hydroxyproline content and nitric oxide level in lung; while, catalase activity was decreased significantly. Consequently, waterpipe smoke exposure for long time caused serious harmful effects on br...
Source: Egyptian Journal of Basic and Applied Sciences - Category: Science Source Type: research

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Source: Clinics - Category: General Medicine Source Type: research
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Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00807
Source: Journal of Medicinal Chemistry - Category: Chemistry Authors: Source Type: research
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Source: Cardiovascular Ultrasound - Category: Radiology Authors: Tags: Review Source Type: research
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Source: Neurological Sciences - Category: Neurology Source Type: research
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Source: Frontiers in Physiology - Category: Physiology Source Type: research
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Source: Journal of Neurology - Category: Neurology Source Type: research
AbstractIn its typical presentation, chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) occurs more often in old males as a progressive/recurrent motor and sensory nerve dysfunction with tendon areflexia. However, CIDP has also atypical clinical presentations, including pure sensory neuropathies, among which chronic immune sensory polyradiculopathy (CISP) accounts for only 0.5% of all CIDP, with no juvenile cases reported as yet. A 17-year-old girl presented for a progressive sensory ataxia and hands clumsiness. Diffuse tendon areflexia and hypokinaesthesia were observed. Motor and sensory nerve conduction st...
Source: Neurological Sciences - Category: Neurology Source Type: research
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Source: Acta Neurologica Belgica - Category: Neurology Source Type: research
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