Bioactive profiling and therapeutic potential of mushroom (Pleurotus tuberregium) extract on Wistar albino rats (Ratus norvegicus) exposed to arsenic and chromium toxicity

Publication date: 2018Source: Toxicology Reports, Volume 5Author(s): Emmanuel Temiotan Ogbomida, Kate Omofonmwan, Igiogbe Aganmwonyi, Iriagbonse Priscillia Fasipe, Alex Enuneku, Lawrence I.N. EzemonyeAbstractMushroom species are valued in gourmet traditions around the world for their unique taste, aroma, nutritional value and medicinal potentials. The bioactive profiling of P. tuberregium mushroom was evaluated to determine it therapeutic effect on Wistar albino rats exposed to arsenic (As) and chromium (Cr) toxicity. Proximate analysis of P. tuberregium showed high composition of carbohydrate (80.24) followed by moisture (21.16), protein (11.46), ash (3.03) and fibre (0.25) content. Phytochemical analysis revealed the presence of polyphenols (2.58), alkaloid (2.46), oxalate (4.25), flavonoid (1.68), tannin (0.38) and Saponin (trace) in trace amount. Mineral analysis yielded variable amounts of Na, Mg, K and Ca. Therapeutics assessment of P. tuberregium to Wistar albino rats exposed to As-Cr toxicity showed improved feed and water intake during the exposure duration. Haematological indices revealed significant increase in platelet (PLT), granulocytes and monocytes while lymphocyte (LY) and red cell distribution width (RDW) were low. Biochemical and redox marker of liver and kidney profiles showed decrease in alkaline phosphatase (ALP), alanine transaminase (ALT) and aspartate transaminase (AST) in the liver. Creatinine and urea in the kidney also decrease while total protein ...
Source: Toxicology Reports - Category: Toxicology Source Type: research