Natural hormone replacement therapy with a functioning ovary after the menopause: dream or reality?

Publication date: Available online 30 June 2018Source: Reproductive BioMedicine OnlineAuthor(s): Jacques Donnez, Marie-Madeleine DolmansAbstractAt the dawn of humanity, it was rare to live beyond the age of 35 years, so the ovary was intended to function for a woman's entire life. Nowadays, it is not unusual for women to live into their 80s. This means that many of them spend 30–40% of their lives in the menopause at increased risk of various conditions associated with an absence of oestrogens (cardiovascular disease, bone mineral density loss). Reimplantation of frozen–thawed ovarian tissue is able to restore long-term ovarian endocrine function that can persist for more than 7 years (12 years if the procedure is repeated). If ovarian tissue reimplantation is capable of restoring ovarian activity after menopause induced by chemotherapy, radiotherapy, surgery, or a combination of all three, why not propose it to recover sex steroid secretion after natural menopause and prevent menopause-related conditions in the ageing population? In this application, the graft site could be outside the pelvic cavity, e.g., forearm or rectus muscle. Could ovarian tissue freezing at a young age followed by reimplantation upon reaching menopause be the anti-ageing therapy of the future? Sufficient existing evidence now surely merits serious debate.
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research

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ConclusionsThe KTC showed protective potentials of ovarian reserve and fertility to attenuate premature ovarian failure, which was relatively associated with activation of the PI3K/AKT/mTOR signaling pathway.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
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Source: Female Pelvic Medicine and Reconstructive Surgery - Category: OBGYN Tags: Original Articles Source Type: research
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Source: Molecular Biology Reports - Category: Molecular Biology Authors: Tags: Mol Biol Rep Source Type: research
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Source: Clinical and Translational Oncology - Category: Cancer & Oncology Source Type: research
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Source: Clinical Genitourinary Cancer - Category: Cancer & Oncology Authors: Tags: Clin Transl Oncol Source Type: research
Conditions:   Hypertension;   Hyperuricemia;   Menopause Interventions:   Drug: Perindopril;   Drug: Hydrochlorothiazide;   Drug: Estracomb TTS Sponsor:   Anna Posadzy-Małaczyńska Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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Source: Seminars in Ultrasound, CT and MRI - Category: Radiology Source Type: research
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Source: Seminars in Reproductive Medicine - Category: Reproduction Medicine Authors: Tags: Review Article Source Type: research
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Source: The Medical Futurist - Category: Information Technology Authors: Tags: Business Future of Medicine Health Sensors & Trackers Telemedicine & Smartphones companies company digital digital health digital health technologies femtech health technology Innovation market women women's health Source Type: blogs
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