Astilbin ameliorates pulmonary fibrosis via blockade of Hedgehog signaling pathway

ConclusionsAstilbin ameliorates pulmonary fibrosis via blockade of Hedgehog signaling pathway and has potential therapeutic value for lung fibrosis treatment.
Source: Pulmonary Pharmacology and Therapeutics - Category: Respiratory Medicine Source Type: research

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Abstract Two factors play the key role in application of hydrogels as biomedical implants (for example, for replacement of damaged intervertebral discs and repair of spinal cord injuries): their stiffness and strength (measured in tensile tests) and mechanical integrity (estimated under uniaxial compression). Observations show a pronounced difference between the responses of hydrogels under tension and compression (the Young's moduli can differ by two orders of magnitude), which is conventionally referred to as the tension-compression asymmetry (TCA). A constitutive model is developed for the mechanical behavior o...
Source: Journal of the Mechanical Behavior of Biomedical Materials - Category: Materials Science Authors: Tags: J Mech Behav Biomed Mater Source Type: research
Abstract Bamboo achieves its mechanical efficiency in bending and compression, meaning mechanical performance per unit mass, due to its hierarchical structure. As an orthotropic tube with a higher strength and stiffness parallel to the tube axis and with a density and property gradient across the tube wall, in which fiber bundles are embedded in a porous matrix, the bamboo culm is both stiffer and stronger in bending and less prone to ovalization and catastrophic failure than an orthotropic tube without property gradients would be. Few engineered materials exist that emulate bamboo's mechanical efficiency. The res...
Source: Journal of the Mechanical Behavior of Biomedical Materials - Category: Materials Science Authors: Tags: J Mech Behav Biomed Mater Source Type: research
This study assessed the glial and fibrotic scar tissue's Young's modulus and composition (scar morphometry, cell identity, extracellular matrix (ECM) makeup) that contribute to the tissue's stiffness. The spatial Young's modulus of a chronic (~18-wks, post-injury) hemi-section, including the glial and fibrotic regions, were significantly less than naïve tissue (~200 Pa; p 
Source: Journal of the Mechanical Behavior of Biomedical Materials - Category: Materials Science Authors: Tags: J Mech Behav Biomed Mater Source Type: research
Abstract Structural repair of soft tissue for regenerative therapies can be advanced by developing biocompatible and bioresorbable materials with mechanical properties similar to the tissue targeted for therapy. Developing new materials modeling soft tissue mechanics can mitigate many limitations of material based therapies, specifically concerning the mechanical stress and deformation the material imposes on surrounding tissue structures. However, many elastomeric materials used in soft tissue repair lack the ability to be delivered through minimally invasive surgical (MIS) or transcatheter routes and require ope...
Source: Journal of the Mechanical Behavior of Biomedical Materials - Category: Materials Science Authors: Tags: J Mech Behav Biomed Mater Source Type: research
Publication date: Available online 22 September 2020Source: Annals of Medicine and SurgeryAuthor(s): C. Paasch, J. Fiebelkorn, G. De Santo, N. Aljedani, P. Ortiz, U. Gauger, K. Boettge, S.H. Full, S. Anders, M. Hünerbein
Source: Annals of Medicine and Surgery - Category: General Medicine Source Type: research
Authors: Chatterjee A, Rajarshi K, Khan R, Ghosh H, Kapoor S, Ray S Abstract There is close interdependence between cell survival, cell senescence, events of the cell cycle, apoptosis, malignancy development, and tumor responses to cancer treatment. Intensive studies and elaborate researches have been conducted on the functional aspects of oncogenes, tumor suppressor genes, apoptotic genes, and members guiding cell cycle regulation. These disquisitions have put forward the existence of a highly organized response pathway termed as a DNAdamage response network. The pathways detecting DNA damage and signaling are int...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research
Fanconi anemia (FA) is a rare multigenic chromosomal instability syndrome that predisposes patients to life-threatening bone marrow failure, congenital malformations, and cancer. Functional loss of interstrand cross-link (ICL) DNA repair system is held responsible, though the mechanism is not yet fully understood. The clinical and molecular findings of 20 distinct FA cases, ages ranging from perinatal stage to 32 years, are presented here. Pathogenic variants inFANCA were found responsible in 75%,FANCC,FANCE,FANCJ/BRIP1,FANCL in 5%, andFANCD1/BRCA2 andFANCN/PALB2 in 2.5% of the subjects. Altogether, 25 different variants i...
Source: Molecular Syndromology - Category: Molecular Biology Source Type: research
Naringin and bone marrow mesenchymal stem cells repair articular cartilage defects in rabbit knees through the transforming growth factor-β superfamily signaling pathway. Exp Ther Med. 2020 Nov;20(5):59 Authors: Ye C, Chen J, Qu Y, Liu H, Yan J, Lu Y, Yang Z, Wang F, Li P Abstract The present study aimed to assess the effect of a combination of naringin and rabbit bone marrow mesenchymal stem cells (BMSCs) on the repair of cartilage defects in rabbit knee joints and to assess possible involvement of the transforming growth factor-β (TGF-β) signaling pathway in this process. After establi...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
Purpose: To visualize foveal microstructures in macula-off rhegmatogenous retinal detachment using swept source optical coherence tomography preoperatively and postoperatively and to investigate the relationship between foveal microstructures and postoperative visual acuity. Methods: We retrospectively analyzed 42 eyes of 42 consecutive patients diagnosed with macula-off rhegmatogenous retinal detachment who underwent anatomically successful repair surgery and were followed up for 6 months. We used swept source optical coherence tomography to investigate the relationship between preoperative and postoperative continui...
Source: RETINA - Category: Opthalmology Tags: Original Study Source Type: research
Conclusion: Areas of previously detached retina exhibit significant fluorescence lifetime changes. We found a significant correlation of fluorescence lifetimes within the fovea with visual acuity after successful RRD repair. Our data suggests that the prolongation of fluorescence lifetimes in the fovea is mainly driven by loss of macular pigment. Therefore, fluorescence lifetime imaging ophthalmoscopy may be useful in the prediction of long-term functional outcomes after macula-off RRD surgery.
Source: RETINA - Category: Opthalmology Tags: Original Study Source Type: research
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