Astilbin ameliorates pulmonary fibrosis via blockade of Hedgehog signaling pathway

ConclusionsAstilbin ameliorates pulmonary fibrosis via blockade of Hedgehog signaling pathway and has potential therapeutic value for lung fibrosis treatment.
Source: Pulmonary Pharmacology and Therapeutics - Category: Respiratory Medicine Source Type: research

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Publication date: Available online 10 August 2019Source: Life SciencesAuthor(s): Jianhua Zeng, Shilang Xiong, Linghua Ding, Jianguo Zhou, Jingtang Li, Peng Qiu, Xingen Liao, Long Xiong, Zhisheng Long, Shiwei LiuAbstractAimsThe present study aimed to investigate the mechanism of bone repair mediated by recombination BMP-2 (rhBMP-2)/recombination CXC chemokine ligand-13 (rhCXCL13)-loaded hollow hydroxyapatite (HA) microspheres/chitosan (CS) composite.Materials and methodsFirstly, the biological activity of rhBMP-2 and rhCXCL13 released from the complex was investigated. Secondly, the effect of rhBMP-2 sustained release solut...
Source: Life Sciences - Category: Biology Source Type: research
Leukemia, Published online: 19 August 2019; doi:10.1038/s41375-019-0542-5Long non-coding RNA NEAT1 targeting impairs the DNA repair machinery and triggers anti-tumor activity in multiple myeloma
Source: Leukemia - Category: Hematology Authors: Source Type: research
Sung-Hsin Kuo Our previous study demonstrated that administration of NVP-BEZ235 (BEZ235), a dual PI3K/mTOR inhibitor, before radiotherapy (RT) enhanced the radiotherapeutic effect in colorectal cancer (CRC) cells both in vitro and in vivo. Here, we evaluated whether maintenance BEZ235 treatment, after combinatorial BEZ235 + RT therapy, prolonged the antitumor effect in CRC. K-RAS mutant CRC cells (HCT116 and SW480), wild-type CRC cells (HT29), and HCT116 xenograft tumors were separated into the following six study groups: (1) untreated (control); (2) RT alone; (3) BEZ235 alone; (4) RT + BEZ235; (5) maintenance BEZ235 f...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
In conclusion, this study elucidated that combination of cisplatin and XAV-939 exerted cytotoxic and genotoxic effect to abrogate CSC mediated chemoresistance in HNSCC in synergistic manner.
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - Category: Genetics & Stem Cells Source Type: research
ConclusionsGeneral surgery residents have gained more experience in some anorectal procedures over time. The required number of procedures to establish competence is not well defined and should be formally evaluated.Graphical abstract
Source: The American Journal of Surgery - Category: Surgery Source Type: research
Publication date: Available online 17 August 2019Source: BurnsAuthor(s): Feng Tian, Yiwen Niu, Yuzhi JiangAbstractScar often occurred during wound repair. It was known that there were differences in collagen structure in dermal tissues at millimeter scale and micron scale, however, it was not known whether there were differences in collagen structure in dermal tissues at nanoscale during wound repair. In order to compare the difference at nanoscale, skin samples from patients were selected, the control groups were the normal skin from the same patients. These samples were tested by the small angle X-ray scattering techniqu...
Source: Burns - Category: Dermatology Source Type: research
This report serves as a preliminary study and may be a surgical option for minimally invasive direct repair.
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
In conclusion, our data show how oncogenic and tumor-suppressive drivers of cellular senescence act to regulate surveillance processes that can be circumvented to enable SnCs to elude immune recognition but can be reversed by cell surface-targeted interventions to purge the SnCs that persist in vitro and in patients. Since eliminating SnCs can prevent tumor progression, delay the onset of degenerative diseases, and restore fitness; since NKG2D-Ls are not widely expressed in healthy human tissues and NKG2D-L shedding is an evasion mechanism also employed by tumor cells; and since increasing numbers of B cells express NKG2D ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Publication date: December 2019Source: Materials Science and Engineering: C, Volume 105Author(s): Mingshu Xiao, Lihu Gao, Arun Richard Chandrasekaran, Jianfeng Zhao, Qian Tang, Zhibei Qu, Fei Wang, Li Li, Yang Yang, Xueli Zhang, Ying Wan, Hao PeiAbstractDevelopment of biomedical materials for proper collagen deposition is of great importance to accelerate wound healing and thus achieving skin regeneration. Here, we report guanosine quartet hydrogels loaded with recombinant human-source collagen (G4-RHC) that can be used as medical patches for wound repair. The G4-RHC hydrogels are flexible, and when wrapped onto the skin s...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Publication date: Available online 16 August 2019Source: Seminars in Cell &Developmental BiologyAuthor(s): Dominic Julian, Ethan W. Hollingsworth, Katherine Julian, Jaime ImitolaAbstractHuman central nervous system (CNS) regeneration is considered the holy grail of neuroscience research, and is one of the most pressing and difficult questions in biology and science. Despite more than 20 years of work in the field of neural stem cells (NSCs), the area remains in its infancy as our understanding of the fundamental mechanisms that can be leveraged to improve CNS regeneration in neurological diseases is still growing. Here...
Source: Seminars in Cell and Developmental Biology - Category: Cytology Source Type: research
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