In vivo and in vitro investigation of anti-inflammatory and mucus-regulatory activities of a fixed combination of thyme and primula extracts

Publication date: August 2018Source: Pulmonary Pharmacology &Therapeutics, Volume 51Author(s): Jan Seibel, Kirill Kryshen, Judit E. Pongrácz, Martin D. LehnerAbstractHypersecretion of viscous mucus is one of the hallmark symptoms of acute and chronic bronchitis and typically develops secondary to an inflammation of the airway epithelium. Bronchipret® TP film-coated tablets (BRO), a herbal medicinal product containing a fixed combination of thyme herb and primula root extracts, has been successfully used clinically for the treatment of acute bronchitis for more than two decades. However, the underlying pharmacological mechanisms of action have not been fully understood so far.We investigated the anti-inflammatory and mucus-regulatory effects of orally administered BRO in an animal model of pulmonary inflammation that was experimentally induced by intratracheal LPS instillation. BRO was administered once daily for up to three days following the induction of inflammation. Treatment with BRO effectively inhibited polymorphonuclear cell influx into the lung as well as the increase in mucin 5ac (MUC5AC) protein. Furthermore, the LPS-induced increase of goblet cell numbers was significantly attenuated by BRO treatment.Subsequent in vitro investigations with IL-13 stimulated human primary respiratory epithelium and the Calu-3 respiratory epithelial cell line in air-liquid-interface culture confirmed the effects on mucus production and goblet cell numbers observed in th...
Source: Pulmonary Pharmacology and Therapeutics - Category: Respiratory Medicine Source Type: research

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I get that in chronic bronchitis, the mucus plugs up the bronchioles and makes it hard for CO2 to get out, so PCO2 goes up and pH goes down. Since emphysema is also an obstructive lung disease, why does PCO2 not go up there as well? (Goljan pg 304)
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Step I Source Type: forums
CONCLUSION: Probable ACO is associated with WTC exposures. Further study of ACO is needed to understand the development of this and other environmentally or occupationally-related airway diseases, and how to prevent these in disasters like 9/11. PMID: 32930623 [PubMed - as supplied by publisher]
Source: Journal of Asthma - Category: Respiratory Medicine Tags: J Asthma Source Type: research
Authors: Stolpe C, Tannapfel A Abstract A 47-year-old male presented with dyspnoea and pulmonary nodules. He had longstanding asthma, chronic rhinosinusitis and a history of seizures, having been treated with valproic acid for years. A transbronchial biopsy and a bronchoalveolar lavage yielded a eosinophilic bronchitis and alveolitis without any malignant cells. The patient was then treated with oral corticosteroids for a few months, and the antiepileptic medication was switched to levetiracetam. Within a few months the dyspnoea improved and both the pulmonary nodules and the eosinophilia in the full blood count re...
Source: Pneumologie - Category: Respiratory Medicine Tags: Pneumologie Source Type: research
Children who suffer a bout of bronchitis at least once before their seventh birthday are at increased risk for developing lung problems such as asthma and pneumonia later in life, a study suggests.Reuters Health Information
Source: Medscape Allergy Headlines - Category: Allergy & Immunology Tags: Pulmonary Medicine News Source Type: news
Publication date: Available online 10 September 2020Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Marta Wiszniewska, Perrine Dellis, Vera van Kampen, Hille Suojalehto, Xavier Munoz, Jolanta Walusiak-Skorupa, Irmeli Lindström, Rolph Merget, Christian Romero-Mesones, Joaquin Sastre, Santiago Quirce, Paola Mason, Catherine Rifflart, Julien Godet, Frédéric de Blay, Olivier Vandenplas, European network for the PHenotyping of OCcupational ASthma (E-PHOCAS)
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
Cystic fibrosis (CF) is caused by autosomal-recessive inheritance of a dysfunctional cystic fibrosis transmembrane conductance regulator (CFTR), up to 90% due to Phe508del mutation in the CFTR gene. We tested the hypothesis that CFTR Phe508del carriers have increased morbidity and mortality versus non-carriers in the general population. We genotyped 108 035 randomly selected white Danish individuals from the Copenhagen General Population Study (aged from 20–100 years) for CFTR Phe508del mutation (rs113993960). Risk of chronic bronchitis and airflow limitation was assessed cross-sectionally. Overall survival and ...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: CF and non-CF bronchiectasis Original Articles: Cystic fibrosis Source Type: research
Authors: Mustafa G, Aslam A, Tipu MY, Masood S, Iqbal U, Mahmood A, Tayyab M, Irshad I PMID: 32896117 [PubMed - in process]
Source: Journal of Biological Regulators and Homeostatic Agents - Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research
Abstract Painful temporomandibular disorders (TMD) in children and adolescents may impact negatively the individual ´s life. The presence of comorbidities associated with TMD tends to increase the persistence of pain and to facilitate its chronification. Objective To investigate the presence of other painful conditions and systemic diseases and their association with painful TMD. Methodology In this cross-se ctional study, 690 adolescents aged between 12-14 years old were evaluated through questionnaires and clinical examinations. Results Painful TMD was found in 16.2% of the sample, with a significant association wi...
Source: Journal of Applied Oral Science - Category: Dentistry Source Type: research
ConclusionIn this study, ingredient analysis, network pharmacology analysis, and experiment verification were combined, and revealed that PG can be used to treat CB by reducing inflammation. Our findings provide novel insight into the mechanism of action of Chinese medicine. Furthermore, our data are of value for the research and development of novel drugs and the application thereof.
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Authors: Lo Bello F, Hansbro PM, Donovan C, Coppolino I, Mumby S, Adcock IM, Caramori G Abstract INTRODUCTION: Chronic obstructive pulmonary disease (COPD) is a lung disease characterised by chronic bronchitis, emphysema, and remodelling. Its prevalence is increasing worldwide, however there are few effective therapies, and none of the treatments currently available prevent the progression of the disease or target all of the hallmark features. The development and progression of COPD is heterogeneous, which has hampered the development of new therapies. AREAS COVERED: In this review, we cover the emergence of th...
Source: Expert Opinion on Emerging Drugs - Category: Drugs & Pharmacology Tags: Expert Opin Emerg Drugs Source Type: research
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