Soy isoflavones improve cardiovascular disease risk markers in women during the early menopause

Publication date: July 2018Source: Nutrition, Metabolism and Cardiovascular Diseases, Volume 28, Issue 7Author(s): T. Sathyapalan, M. Aye, A.S. Rigby, N.J. Thatcher, S.R. Dargham, E.S. Kilpatrick, S.L. AtkinAbstractBackgroundHormone replacement therapy may be beneficial for cardiovascular disease risk (CVR) in post-menopausal women. Soy isoflavones may act as selective estrogen receptor modulators. The aim of this study was to evaluate whether soy isoflavones had an effect on CVR markers.MethodsThe expected 10-year risk of cardiovascular disease and mortality were calculated as a secondary endpoint from a double blind randomised parallel study involving 200 women (mean age 55 years, Caucasian, Hull, UK, 2012) in the early menopause who were randomised to 15 g soy protein with 66 mg isoflavone (SPI) or 15 g soy protein alone (depleted of all isoflavones; SP) given as a snack bar between meals daily for 6 months. Age, diabetes, smoking, blood pressure and lipid profiles were used to calculate CVR using the Framingham CVR engine.ResultsSPI treatment resulted in a significant reduction in the metabolic parameters and systolic blood pressure compared to SP (p 
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research

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Conclusions Aging leads to a progressive decrease in androgen production that, in turn, leads to the development of LOH, defined by significant low T serum levels (in the lowest quartile) in the presence of signs and symptoms of hypogonadism (51). LOH could be due to both testicular and hypothalamic-pituitary dysfunction (32), and ED is one of its main symptoms. ED in LOH is linked to increased oxidative stress, subclinical inflammation, and subsequent endothelial dysfunction (101). In elderly men, it has been shown that LOH is also linked to lower cAMP pool and to an alteration of the cGMP signaling pathway. PDE5 gene l...
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Publication date: July 2018Source: Nutrition, Metabolism and Cardiovascular Diseases, Volume 28, Issue 7Author(s): T. Sathyapalan, M. Aye, A.S. Rigby, N.J. Thatcher, S.R. Dargham, E.S. Kilpatrick, S.L. AtkinAbstractBackgroundHormone replacement therapy may be beneficial for cardiovascular disease risk (CVR) in post-menopausal women. Soy isoflavones may act as selective estrogen receptor modulators. The aim of this study was to evaluate whether soy isoflavones had an effect on CVR markers.MethodsThe expected 10-year risk of cardiovascular disease and mortality were calculated as a secondary endpoint from a double blind rand...
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
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