Transient impairment of olfactory threshold in acute multiple sclerosis relapse

Publication date: July 2018Source: Multiple Sclerosis and Related Disorders, Volume 23Author(s): Gabriel Bsteh, Harald Hegen, Felix Ladstätter, Klaus Berek, Matthias Amprosi, Sebastian Wurth, Michael Auer, Franziska Di Pauli, Florian Deisenhammer, Andreas Lutterotti, Thomas BergerAbstractBackgroundImpairment of olfactory threshold is a feature of early and active relapsing remitting multiple sclerosis (RRMS). It predicts inflammatory disease activity and was reported to be transient. However, the timing of onset and resolve of olfactory threshold impairment remains unclear.ObjectiveTo prospectively assess the development of olfactory threshold in acute MS relapse over time in comparison to stable MS patients.MethodsIn a prospective observational design, we measured olfactory threshold by performing the Sniffin’ Sticks test (minimum score 0, maximum score 16 reflecting optimal olfactory function) at baseline and after 4, 12 and 24 weeks. We included 30 RRMS patients with acute MS relapse and 30 clinically stable RRMS patients (defined as no relapse within the last 12 months) as a control group.ResultsOlfactory threshold was impaired in patients with acute MS relapse at baseline (median difference = −3.5; inter-quartile range [IQR] −4.5– − 2.5; p 
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research

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We present five teriflunomide-treated patients with MS who subsequently developed active COVID-19 infection. The patients continued teriflunomide therapy and had self-limiting infection, without relapse of their MS. These observations have implications for the management of MS in the setting of the COVID-19 pandemic.
Source: Journal of Neurology - Category: Neurology Source Type: research
A critical role for IL-17, a cytokine produced by T helper 17 (Th17) cells, has been indicated in the pathogenesis of chronic inflammatory and autoimmune diseases. A positive effect of blockade of IL-17 secreted by autoreactive T cells has been shown in various inflammatory diseases. Several cytokines, whose production is affected by environmental factors, control Th17 differentiation and its maintenance in tissues during chronic inflammation. The roles of IL-17 in the pathogenesis of chronic neuroinflammatory conditions, multiple sclerosis (MS), experimental autoimmune encephalomyelitis (EAE), Alzheimer's disease, and isc...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
AbstractMultiple sclerosis (MS) is a neuroinflammatory disease in which unresolved and uncontrolled inflammation disrupts normal cellular homeostasis and leads to a pathological disease state. It has long been recognized that endogenously derived metabolic by-products of omega fatty acids, known as specialized pro-resolving lipid mediators (SPMs), are instrumental in resolving the pathologic inflammation. However, there is minimal data available on the functional status of SPMs in MS, despite the fact that MS presents a classical model of chronic inflammation. Studies to date indicate that dysfunction of the SPM biosynthet...
Source: Clinical Reviews in Allergy and Immunology - Category: Allergy & Immunology Source Type: research
The U.S. Food and Drug Administration has extended the review period for Novartis AG's multiple sclerosis drug ofatumumab by three months, the company said on Tuesday.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
This study aims to identify reliable and objective gait-based biomarkers to monitor progressive multiple sclerosis (MS) in clinical s...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news
Authors: Smolders J, Fransen NL, Hsiao CC, Hamann J, Huitinga I Abstract INTRODUCTION: Multiple sclerosis (MS) is characterized by inflammatory attacks of infiltrating leukocytes at onset but evolves into a smoldering, progressive disease within the central nervous system at its later stages. The authors discuss the contribution of white matter lesions to the pathology of advanced MS, thereby paying particular attention to the role of T cells. AREAS COVERED: Diagnostic biopsy and autopsy studies of white matter lesions in early MS show different pathological patterns of demyelination and leukocyte infiltration. Bra...
Source: Expert Review of Neurotherapeutics - Category: Neurology Tags: Expert Rev Neurother Source Type: research
Publication date: Available online 2 June 2020Source: Multiple Sclerosis and Related DisordersAuthor(s): Virginia Meca-Lallana, Clara Aguirre, Laura Cardeñoso, Teresa Alarcon, Angels Figuerola-Tejerina, Beatriz del Río, Miguel Ruiz Álvarez, José Vivancos
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Condition:   Secondary Progressive Multiple Sclerosis Interventions:   Drug: SAR442168;   Drug: Placebo to match SAR442168 Sponsor:   Sanofi Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Multiple Sclerosis Intervention:   Device: DreaMS Sponsor:   Research Center for Clinical Neuroimmunology and Neuroscience Basel Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Secondary Progressive Multiple Sclerosis Interventions:   Drug: SAR442168;   Drug: Placebo to match SAR442168 Sponsor:   Sanofi Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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