TGF-β1 modulates podocyte migration by regulating the expression of integrin-β1 and -β3 through different signaling pathways

This study provides a novel mechanism for TGF-β1 signaling in regulating podocyte migration.Graphical abstractTGF-β1 inhibits integrin-β1 maturation through MAP kinases pathway, but increases integrin-β3 expression through Smad2/3 and MAP kinases pathways in podocytes. The increased integrin-β3 promotes podocyte adhesion and migration that may lead to foot process effacement.
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research