Role of Streptococcus mutans surface proteins for biofilm formation
Publication date: February 2018Source: Japanese Dental Science Review, Volume 54, Issue 1Author(s): Michiyo Matsumoto-NakanoSummaryStreptococcus mutans has been implicated as a primary causative agent of dental caries in humans. An important virulence property of the bacterium is its ability to form biofilm known as dental plaque on tooth surfaces. In addition, this organism also produces glucosyltransferases, multiple glucan-binding proteins, protein antigen c, and collagen-binding protein, surface proteins that coordinate to produce dental plaque, thus inducing dental caries. Bacteria utilize quorum-sensing systems to modulate environmental stress responses. A major mechanism of response to signals is represented by the so called two-component signal transduction system, which enables bacteria to regulate their gene expression and coordinate activities in response to environmental stress. As for S. mutans, a signal peptide-mediated quorum-sensing system encoded by comCDE has been found to be a regulatory system that responds to cell density and certain environmental stresses by excreting a peptide signal molecule termed CSP (competence-stimulating peptide). One of its principal virulence factors is production of bacteriocins (peptide antibiotics) referred to as mutacins. Two-component signal transduction systems are commonly utilized by bacteria to regulate bacteriocin gene expression and are also related to biofilm formation by S. mutans.
Lactobacillus spp. play a major role in the development of dental caries. Although effective methods are known for the prevention and management of dental caries, its prevalence of dental caries is increasing amo...
Despite great improvement in child oral health, some children subgroups still suffer from higher levels of dental caries. Geographic and socioeconomic barriers and the lack of access to dental care services ar...
Conclusion: The new tool has sound psychometric properties, is relatively short, culturally equivalent, age-specific, and can assess both positive and negative aspects of adolescent oral health. Further testing in longitudinal studies is required to determine its usefulness as an outcome measure.
Conclusion: This study showed a high prevalence of dental caries, periodontal problem, and tooth wear. This emphasizes the need for community-based awareness program on dental health and recommends periodic dental health screening program at the community level for early diagnosis and better treatment.
Conclusion: Genomic DNA of S. mutans was successfully isolated from the rural population. Dex gene was successfully amplified using PCR. Hae III enzymes successfully digested PCR amplicons and the fragments exhibited visible heterogeneity.
Conclusion: Dental caries continues to be a prominent oral health problem among children in the SEAR countries with huge variation in the prevalence across ages and countries. This review results can be used to update the “WHO Oral Health Country/Area Profile Program” for dental caries among children for SEAR.
Conclusions: High socioeconomic status of parents had a significant role on increased dental caries experience among children.
CONCLUSION: The direction of causality between oral health and depression is unclear; however, oral health may contribute to depression in older Australian men and depressive symptoms may limit chewing capacity and be aggravated by untreated dental decay. PMID: 31943668 [PubMed - as supplied by publisher]
CONCLUSION: Strong evidence indicates that epigenetic changes participate in the pathogenesis of oral diseases and epigenetic targeting may be considered as a complementary therapeutic scheme to current management of oral health. PMID: 31942842 [PubMed - as supplied by publisher]
Publication date: Available online 9 January 2020Source: Journal of Oral and Maxillofacial Surgery, Medicine, and PathologyAuthor(s): Kenjiro Okamoto, Itaru Tojyo, Yukari Shintani, Takashi Nakanishi, Naoki Mizobata, Yuya Takeda, Shigeru Suzuki, Shinsuke Ieda, Masamichi Ueda, Nobuo Kanazawa, Shigeyuki FujitaAbstractNakajo-Nishimura syndrome, which is a specific autoimmune disorder characterized by chronic inflammation, emaciation, and exhaustion, is inherited in an autosomal recessive fashion and is representative of proteasome dysfunction. Its main clinical features include pernio-like red-to-purple skin plaques on the han...