Dual input computed tomography perfusion in evaluating the therapeutic response of transarterial chemoembolization for hepatocellular carcinoma

This study included 31(86%) male and 5(14%) female HCC patients with mean age (54 years). The residual lesion was observed in 25 patients of the 36 patients with increased CT attenuation value(HU), AFP (ml/min/100 ml), HPI (%) and decreased PVP (ml/min/100 ml) in the residual disease compared to surrounding cirrhotic liver parenchyma with P value 
Source: The Egyptian Journal of Radiology and Nuclear Medicine - Category: Nuclear Medicine Source Type: research

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Conclusions Dynamic contrast-enhanced GRASP MRI allows for a reliable and robust assessment of hepatic perfusion parameters providing quantitative results comparable to VPCT and enables characterization of HCC before and after TACE, thus posing the potential to serve as an alternative to VPCT.
Source: Investigative Radiology - Category: Radiology Tags: Original Articles Source Type: research
CONCLUSION: CEUS may be useful for the early prediction of tumor response to lenvatinib therapy in patients with unresectable HCC. PMID: 31148907 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - Category: Gastroenterology Authors: Tags: World J Gastroenterol Source Type: research
Conclusions Several model systems are now available to characterize the MSC-tumour interplay in the TME. These offer early promise in establishing robust preclinical platforms for the identification of crucial molecular pathways and for the assessment of clinical efficacy of novel drugs to inhibit cancer development and progression. However, selection of the right model for a given study should be shaped on the purpose, and should also consider fixed biological, biochemical, and biophysical parameters according to the specific tumour type. Finally, in order to get reliable and useful results to be translated to the clinic...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Conclusion: Fat fraction on MRI corresponded to fat content on histology and therefore contributes to lesion characterization. Measurement repeatability was excellent for ADC; this parameter increased significantly post-radiotherapy even in disease categorized as stable by size criteria, and corresponded to cellularity on histology. ADC can be utilized for characterizing and assessing response in heterogeneous retroperitoneal sarcomas. Introduction Soft-tissue sarcomas are often highly heterogeneous tumors with variable components that can include cellular tumor, fat, necrosis, and cystic change. In many soft-tissue ...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 7 March 2019Source: Academic RadiologyAuthor(s): Davide Ippolito, Anna Pecorelli, Giulia Querques, Silvia Girolama Drago, Cesare Maino, Cammillo Talei Franzesi, Adam Hatzidakis, Sandro SironiEarly diagnosis of HCC is of paramount importance in order to enable the application of curative treatments. Among these, radiofrequency ablation (RFA) is actually considered the most effective ablative therapy for early stage hepatocellular carcinoma (HCC) not suitable for surgery. On the other hand, transarterial chemoembolization (TACE) represents the standard of care for intermediate stage HCC and...
Source: Academic Radiology - Category: Radiology Source Type: research
Conclusion Preliminary results suggest that pCT adds quantitative data of vascularization, thus demonstrating its usefulness in the assessment of therapeutic response to sorafenib in advanced HCC, in line with mRECIST criteria, offering 1-step information on tissue cellularity and vascularization.
Source: Journal of Computer Assisted Tomography - Category: Radiology Tags: Abdominal Imaging Source Type: research
Conclusions: CTP might be applied to evaluate therapeutic effects of sorafenib in advanced HCC, where HAF could potentially serve as imaging biomarkers for monitoring early therapeutic effects after treatment.
Source: Journal of Cancer Research and Therapeutics - Category: Cancer & Oncology Authors: Source Type: research
ConclusionThis method using a commercially available workstation and liver analysis software can be useful for estimating the embolic area in cTACE.
Source: CardioVascular and Interventional Radiology - Category: Radiology Source Type: research
ConclusionsTumor and liver perfusion parameters estimated from preprocedure triphasic CT were predictive of survival after embolization. Arterial-phase enhancement and histology (degree of differentiation or MVI) did not predict immediate response or overall survival after particle embolization.
Source: Academic Radiology - Category: Radiology Source Type: research
Publication date: Available online 25 October 2018Source: Academic RadiologyAuthor(s): Wolfgang M. Thaiss, Ulrike Haberland, Sascha Kaufmann, Tobias Hepp, Maximilian Schulze, Anya C. Blum, Dominik Ketelsen, Konstantin Nikolaou, Marius Horger, Alexander W. SauterRationale and ObjectivesWe assessed the value of iodine concentration (IC) as a perfusion-derived response marker for hepatocellular carcinoma (HCC) treated with transarterial chemoembolization (TACE) in comparison with volume perfusion computed tomography (VPCT) parameters.Materials and MethodsForty-one HCC lesions in 32 patients examined before and after TACE were...
Source: Academic Radiology - Category: Radiology Source Type: research
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