Inflammatory and oxidative stress parameters as potential early biomarkers for silicosis

Publication date: September 2018Source: Clinica Chimica Acta, Volume 484Author(s): Jessica Nardi, Sabrina Nascimento, Gabriela Göethel, Bruna Gauer, Elisa Sauer, Nuryan Fão, Larissa Cestonaro, Caroline Peruzzi, Jorge Souza, Solange Cristina GarciaAbstractWorkers involved in mining activities are exposed to crystalline silica, which leads to constant pulmonary inflammatory reactions and severe oxidative damage, resulting in silicosis. In this work, we aimed to evaluate inflammatory and oxidative stress parameters as potential early biomarkers of effect to assess crystalline silica toxicity in workers who had occupational exposure during mining. We enrolled 38 workers exposed to crystalline silica (WECS), 24 individuals with silicosis (IWS), and 30 occupationally unexposed workers (OUW), a total of 92 participants. The WECS were divided into 2 groups, according to the time of exposure: 19 workers with 1–15 years of occupational exposure (WECS I) and 19 workers with>16 years of occupational exposure (WECS II). The inflammatory parameters assessed were L-selectin, β-2 integrin, and intercellular adhesion molecule-1 (ICAM-1) surface protein expression in lymphocytes and monocytes, complement C3 and C4, high sensitivity C-reactive protein (hsCRP), and adenosine deaminase (ADA) in serum. Plasma levels of malondialdehyde (MDA) and serum levels of vitamin C were determined as biomarkers of oxidative stress. Biochemical and hematological parameters were also investigated. L-se...
Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research