CXCL13 concentrations in cerebrospinal fluid of patients with Lyme neuroborreliosis and other neurological disorders determined by Luminex and ELISA

Publication date: July 2018Source: Ticks and Tick-borne Diseases, Volume 9, Issue 5Author(s): Mateusz Markowicz, Anna-Margarita Schötta, Michael Kundi, Petra Bogovič, Katarina Ogrinc, Franc Strle, Gerold StanekAbstractThe aims of the study were to determine and compare the concentration of CXCL13 in cerebrospinal fluid (CSF) of patients with Lyme neuroborreliosis (LNB) and various other neurological disorders applying a Luminex based assay and ELISA, and to find factors associated with CXCL13 concentration. CSF samples obtained from four clinically well-defined groups of patients (proven LNB, suspected LNB, tick-borne encephalitis (TBE), and aseptic meningitis/meningoencephalitis other than TBE) – 25 samples per group – were analyzed. The performance of the Luminex recomBead CXCL13 assay (Microgen, Neuried, Germany) and ELISA (Euroimmun, Lübeck, Germany) was assessed by receiver operating characteristics. CXCL13 cut-off values were presented as functions of CSF lymphocyte/monocyte counts. Demographic variables, CSF findings, and history of erythema migrans were assessed as possible predictors for CXCL13 CSF concentrations by a general linear model. The calculated cut-off values determined by the maximum of the Youden index were>131 pg/mL for recomBead and>259 pg/mL for the ELISA. RecomBead showed a sensitivity of 88% (68.8–97.5%) and a specificity of 94% (83.5–98.7%). For the ELISA the corresponding values were 84% (63.9–95.5...
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research

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CONCLUSION: The varying methods of treatment and medication strategies reflect the different setup and concept of the respective hospitals. Indications of dangerous medication trials were not detected. PMID: 30777487 [PubMed - as supplied by publisher]
Source: Zeitschrift fur Kinder- und Jugendpsychiatrie und Psychotherapie - Category: Child Development Tags: Z Kinder Jugendpsychiatr Psychother Source Type: research
This study investigates the relationship between adverse childhood experiences (ACEs), age, and sex with respect to their avatar preference in online games. The analyses comprise a subsample of n = 1817 adolescents and adults from 14 to 60 years within a representative German population-based study. Results indicate that 14 % of this sample uses avatars in online games, with significantly more males (22.6 %) than females (7.7 %) doing so. Persons with multiple ACEs (≥ 4) have a higher OR of 2.05 (95 % CI: 1.418-2.956) to use avatars in online games. Regarding avatar preference, females are more likely to play supporters...
Source: Zeitschrift fur Kinder- und Jugendpsychiatrie und Psychotherapie - Category: Child Development Tags: Z Kinder Jugendpsychiatr Psychother Source Type: research
Conclusion: This case was the first CNS clinical autopsy performed in the state of Paraná and, possibly, in southern Brazil. The death was due to an infectious disease, which was the main cause of death in Brazil in the 1950s.RESUMO Objetivo: A hist ória da Anatomia Patológica no Estado do Paraná, sul do Brasil, está ligada com a fundação da Universidade Federal do Paraná (UFPR). Este estudo identificou a primeira autópsia clínica do sistema nervoso central (SNC) realizada pelo Departamento de Anatomia Patológica da UFPR. Métodos: F oi real...
Source: Arquivos de Neuro-Psiquiatria - Category: Neurology Source Type: research
We report a case of neurosyphilis presented with rapidly progressive dementia along with psychotic symptoms. PMID: 30785032 [PubMed - as supplied by publisher]
Source: Asian Journal of Psychiatry - Category: Psychiatry Tags: Asian J Psychiatr Source Type: research
Publication date: Available online 20 February 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Priscilla H. Wong, Rachel U. Lee
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
Conditions:   Physical Activity;   Psychiatric Disorder Intervention:   Diagnostic Test: The Exercise in Mental Illness Questionnaire (EMIQ) Sponsor:   Charite University, Berlin, Germany Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Lucy Evans, 20, was diagnosed with the brain-inflammation condition encephalitis six weeks after her delusions started and treated at Morriston Hospital in Cwmrhydyceirw, Swansea.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Lucy Evans had encephalitis, an inflammation of the brain that caused her frightening delusions.
Source: BBC News | Health | UK Edition - Category: Consumer Health News Source Type: news
Roberto Savio is founder of IPS Inter Press Service and President EmeritusBy Roberto SavioROME, Feb 21 2019 (IPS)I have been a member of the first international party: the Transnational Radical Party, founded in 1956 by Marco Pannella and Emma Bonino. Then in 1988, I was a wetness of the large protest, in Berlin West, against the meeting of the International Monetary Fund and the World Bank, a precursor of the “Battle of Seattle” in 1988, where 40.000 protesters disrupted the annual meeting of the two world’s financial institutions. I was even detained for a day by the police, even if was just a witness: ...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Civil Society Crime & Justice Development & Aid Economy & Trade Environment Featured Global Global Governance Globalisation Headlines Health Human Rights Inequity South-South TerraViva United Nations Source Type: news
Publication date: July 2018Source: Ticks and Tick-borne Diseases, Volume 9, Issue 5Author(s): Mateusz Markowicz, Anna-Margarita Schötta, Michael Kundi, Petra Bogovič, Katarina Ogrinc, Franc Strle, Gerold StanekAbstractThe aims of the study were to determine and compare the concentration of CXCL13 in cerebrospinal fluid (CSF) of patients with Lyme neuroborreliosis (LNB) and various other neurological disorders applying a Luminex based assay and ELISA, and to find factors associated with CXCL13 concentration. CSF samples obtained from four clinically well-defined groups of patients (proven LNB, suspected LNB, tick-born...
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
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