Investigating Structure and Dynamics of Proteins in Amorphous Phases Using Neutron Scattering

We describe the use of small-angle neutron scattering to study the solution structure of biological molecules and the packing arrangement in amorphous phases, that is, frozen glasses and freeze-dried protein powders. In addition, we discuss the use of neutron spectroscopy to measure the dynamics of glassy systems at different time and length scales. Overall, we expect that the present article will guide and prompt the use of neutron scattering to provide unique insights on many of the outstanding questions in biotechnology.
Source: Computational and Structural Biotechnology Journal - Category: Biotechnology Source Type: research