Can deep learning monitor lesions on F-18 NaF PET/CT?

Deep learning can classify bone lesions found on F-18 sodium fluoride (NaF)...Read more on AuntMinnie.comRelated Reading: Group uses AI to assess mammo interpretation bias SNMMI: AI enables stress-first SPECT MPI protocol SNMMI: Early prostate cancer therapy extends lives SNMMI: AI can predict survival in sarcoma patients AI algorithm can classify bone lesions on PET/CT images
Source: Headlines - Category: Radiology Source Type: news

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Selinexor (KPT-330) is a selective inhibitor of nuclear export (SINE) which specifically targets XPO1 (Exportin 1)-mediated nuclear export, leading to increased nuclear retention of major tumor suppressor proteins and inducing selective apoptosis in cancer cells. Several phase I and II clinical trials demonstrate evidence of anti-cancer activity of Selinexor in solid tumors (i.e metastatic prostate cancer (PMID: 29487219), advanced refractory bone or soft tissue sarcoma (PMID: 27458288) and non-small cell lung cancer (PMID: 28647672); as well as, hematological malignancies, including non-Hodgkin lymphoma (PMID: 28468797), ...
Source: Blood - Category: Hematology Authors: Tags: 652. Myeloma: Pathophysiology and Pre-Clinical Studies, excluding Therapy: Poster II Source Type: research
ConclusionsDisease ‐specific survival and OS for non‐rhabdomyosarcoma histologies appear inferior to those of rhabdomyosarcoma. The addition of RT to surgical resection may improve DSS in locally advanced non‐rhabdomyosarcoma. This is the largest report of the incidence, stage distribution, and survival for this extremely rare urologic malignancy providing valuable prognostic information.
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
Authors: Abstract The interaction between pituitary hormones, GH - PRL, and Growth Factors, GF, plays a fundamental role in the physiological and neoplastic mechanisms of growth, the latter using these factors to a much greater extent compared to the former, with a direct dose-dependent effect on the speed of local or metastatic expansion. In hormone-dependent tumours, the respective male and female sex hormones interact with GH - PRL - GF to sustain the expansion of the tumour. We carried out a review of the literature on the relationship between the expression of GH and GHR in tumour tissues compared to healthy ...
Source: Neuroendocrinology Letters - Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research
Publication date: Available online 21 September 2018Source: The Lancet HIVAuthor(s): Nancy A Hessol, Hannah Whittemore, Eric Vittinghoff, Ling C Hsu, Danning Ma, Susan Scheer, Sandra K SchwarczSummaryBackgroundCancer survivors are at increased risk for subsequent primary cancers. People living with HIV are at increased risk for AIDS-defining and non-AIDS-defining cancers, but little is known about their risk of first versus second primary cancers. We identified first and second primary cancers that occurred in above population expected numbers among people diagnosed with HIV in San Francisco, and compared first and second ...
Source: The Lancet HIV - Category: Infectious Diseases Source Type: research
This invention concerns several high-affinity monoclonal antibodies that can be used to treat FGFR4-related diseases. In particular, these antibodies have been used to generate ADCs and CARs specifically targeting and killing cancer cells.Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children and adolescents. Although current treatments for primary disease are relatively successful, metastatic RMS is generally accompanied by a dismal prognosis. Thus, there is a public health need for the development of new therapies for metastatic RMS.Fibroblast Growth Factor Receptor 4 (FGFR4) is a cell surface protein ...
Source: NIH OTT Licensing Opportunities - Category: Research Authors: Source Type: research
PHILADELPHIA - Artificial intelligence (AI) analysis of stress SPECT myocardial...Read more on AuntMinnie.comRelated Reading: SNMMI: Early prostate cancer therapy extends lives SNMMI: New therapy aids patients with neuroendocrine tumors SNMMI: AI can predict survival in sarcoma patients SNMMI 2018: A year of promotion and ongoing challenges ASNC releases new guidelines for SPECT MPI
Source: Headlines - Category: Radiology Source Type: news
PHILADELPHIA - Providing lutetium-177 prostate-specific membrane antigen radioligand...Read more on AuntMinnie.comRelated Reading: Annals: Overdiagnosis must be better defined SNMMI: New therapy aids patients with neuroendocrine tumors SNMMI: AI can predict survival in sarcoma patients SNMMI 2018: A year of promotion and ongoing challenges Faster MRI protocol avoids unneeded prostate biopsies
Source: Headlines - Category: Radiology Source Type: news
CONCLUSION: Substantial risk of SPT, especially for in-field sarcoma and tongue cancers, exists after definitive IMRT for NPC. SPT severely negates longevity of NPC survivors. High awareness and careful surveillance is warranted for this late lethal complication. PMID: 29932287 [PubMed - as supplied by publisher]
Source: Clinical Prostate Cancer - Category: Cancer & Oncology Authors: Tags: Asia Pac J Clin Oncol Source Type: research
Synovial sarcoma (SS) is a highly aggressive malignant soft tissue sarcoma with typical characteristics of both epithelial and mesenchymal differentiation. Matrix metalloproteinase-14 (MMP-14) is reported to play an important role in some of these tumors. It induces epithelial-to-mesenchymal transition (EMT) in some carcinomas, such as breast and prostate cancers. However, the role of MMP-14 in the pathogenesis of SS remains unclear. Therefore, we investigated the role of MMP-14 and EMT/mesenchymal-to-epithelial transition (MET) in SS.
Source: Human Pathology - Category: Pathology Authors: Tags: Original contribution Source Type: research
Rationale: Multiple primary neoplasms (MPNs) are rare. Most MPNs are double, and triple primary neoplasms are extremely rarer. Here, we describe a case of a 66-year-old man diagnosed with metachronous triple primary neoplasms with primary prostate cancer, lung cancer and colon cancer. Patient concerns: The patient complained of dysuria in January 2015, and he underwent transurethral resection of the prostate. The pathological results showed acinar adenocarcinoma of prostate with a Gleason score of 3+3. In January 2017, he complained of lower abdominal pain, then he took an enteroscopy examination, found a mass in the ...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
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