Circadian clock pathway genes associated with colorectal cancer risk and prognosis.

Circadian clock pathway genes associated with colorectal cancer risk and prognosis.
Arch Toxicol. 2018 Jul 02;:
Authors: Gu D, Li S, Ben S, Du M, Chu H, Zhang Z, Wang M, Zhang ZF, Chen J
Abstract
Circadian clock genes influence biological processes and may be involved in tumorigenesis. We systematically evaluated genetic variants in the circadian clock pathway genes associated with colorectal cancer risk and survival. We evaluated the association of 119 single nucleotide polymorphisms (SNPs) in 27 circadian clock pathway genes with the risk of colorectal cancer in a case-control study (1150 cases and 1342 controls). The false discovery rate (FDR) method was applied to correct for multiple comparisons. Gene-based analysis was performed by the sequence kernel association test (SKAT). Cox proportional hazards regression was used to calculate the effects of SNPs on the overall survival of patients. We identified that compared to those with the G allele, individuals with the rs76436997 A allele in RORA had a significant 1.33-fold increased risk of colorectal cancer (P = 3.83 × 10- 4). Specifically, the GA/AA genotypes were related to an enhanced risk of colorectal cancer compared with that associated with the GG genotype, which was more common in patients with well and moderately differentiated tumors and Dukes A/B stages. The SNP rs76436997 significantly increased the overall survival time of colorectal cancer patients (P =â...

Source: Archives of Toxicology - July 2, 2018 Category: Toxicology Authors: Gu D, Li S, Ben S, Du M, Chu H, Zhang Z, Wang M, Zhang ZF, Chen J Tags: Arch Toxicol Source Type: research