Sleep disorder linked with changes to brain structure typical of dementia
(European Lung Foundation) Obstructive sleep apnea is associated with changes to the structure of the brain that are also seen in the early stages of dementia, according to a study published in the European Respiratory Journal.
MONDAY, July 9, 2018 -- Obstructive sleep apnea (OSA) is associated with changes to the structure of the brain that are seen in the early stages of dementia, according to a study published online July 5 in the European Respiratory Journal. Nathan E....
A new study finds that obstructive sleep apnea is tied to brain structure alterations found in early dementia and that low blood oxygen might be a factor.
CONCLUSION: Multimorbidity is associated with preclinical AD imaging markers of neurodegeneration, but not with amyloid. PMID: 29953971 [PubMed - as supplied by publisher]
Conclusion: Multimorbidity is associated with preclinical AD imaging markers of neurodegeneration, but not with amyloid.Dement Geriatr Cogn Disord 2018;45:272 –281
Conclusions: A brief educational pamphlet written using health literacy concepts was considered valuable and improved patient knowledge and intention to discuss OSA screening with a physician. Further work is needed to determine whether the pamphlet can promote a discussion and referral for OSA screening at the primary care level.
Purpose of review Research interest in sleep as a risk factor for dementia has grown, warranting an update in advances over the last 18 months, particularly in the mild cognitive impairment (MCI) stage in which interventions may be best targeted. Recent findings The current systematic review includes empiric research articles published since 2016 that have investigated sleep (excluding obstructive sleep apnea) in MCI. Published articles include case–control studies, those examining clinical correlates of sleep problems, sleep microarchitecture, neuroimaging studies and novel cerebrospinal and blood-based markers...
Introduction: Obstructive Sleep Apnea Syndrome (OSA) appears to be involved in the cognitive decline. Atrial fibrillation (AF) may produce multiple cerebral ischemic areas due to microembolic phenomena and transient hypoperfusion, eventually leading to a progressive cognitive impairment and even to acclaimed vascular dementia. In the same time, OSA is common among patients with atrial fibrillation.
: In "Prolonged sleep duration as a marker of early neurodegeneration predicting incident dementia," Westwood et al. found an association between long sleep duration and incident dementia. Liguori et al. propose obstructive sleep apnea (OSA) as a possible link between increased sleep duration and neurodegeneration.
I read with interest the article by Westwood et al.,1 which implicated prolonged sleep duration as a potential marker of early-onset neurodegeneration and subsequent dementia. There is possibly a pivotal role of fragmented, and thereby disturbed, sleep hygiene in patients with obstructive sleep apnea. These patients spend minimal time of their sleep in the REM phase, which is crucial for clearance of metabolic waste, especially β-amyloid plagues, through the paravascular pathways in the brain.2 This is accountable for early neurodegenerative processes. Further studies monitoring total time spent in each phase of sleep...
This study tested the hypotheses that late-midlife obstructive sleep apnea (OSA) and short and long sleep duration are associated with dementia for more than 15 years of follow-up. METHODS: A total of 1667 Atherosclerosis Risk in Communities Study participants underwent in-home polysomnography (1996-1998) and were followed for dementia. Dementia was defined by (1) hospitalization diagnosis codes (1996-2012) and (2) a comprehensive neurocognitive examination (2011-2013) with adjudication. RESULTS: OSA and sleep duration were not associated with risk of incident dementia. When using adjudicated outcomes, severe OSA (≥30 vs.