TNF signalling via the TNF receptors mediates the effects of exercise on cognition-like behaviours.

DISCUSSION: TNF receptor signalling via the TNFR1 and TNFR2 appears to mediate the effects of exercise on cognitive-like behaviours. The potential for exercise to regulate human TNF and TNF signalling and cognitive dysfunction needs investigation under inflammatory conditions including depression and neuropsychiatric disorders. PMID: 29969604 [PubMed - as supplied by publisher]
Source: Behavioural Brain Research - Category: Neurology Authors: Tags: Behav Brain Res Source Type: research

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Preoperative and postoperative mental health status (MHS) of total joint arthroplasty patients can affect immediate and long-term outcomes following surgery. Alterations in MHS can be acute or chronic. The most common etiologies include acute changes due to (1) delirium or stroke, (2) movement disorders (Alzheimer dementia, Parkinson disease, multiple sclerosis, epilepsy), and (3) mood/behavior disorders (major depressive disorder, anxiety, bipolar disorder, schizophrenia). Across etiologies, alterations in MHS are associated with worse clinical/patient-reported outcomes and greater total cost of care. Prevention via pharm...
Source: Techniques in Orthopaedics - Category: Orthopaedics Tags: Symposium Source Type: research
An in-depth look at violence and its relation to schizophrenia. Is violence a symptom of schizophrenia? Do mass attackers always have schizophrenia? Are schizophrenics dangerous? Studies say people with schizophrenia are more likely to be a victim of a crime than the perpetrator. However, James Holmes, the movie theater mass murderer, was said to have paranoid schizophrenia. And a person can plead not-guilty by reason of insanity in court. This seems to be contrary to the idea of non-violence in mental illness. Host Rachel Star Withers, a diagnosed schizophrenic, and co-host Gabe Howard delve into these intense subjects i...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Inside Schizophrenia Stigma Violence and Aggression Mental Disorder Mental Health Mental Illness Paranoid Schizophrenia violence and mental illness violence and mentally ill Source Type: blogs
    What is schizophrenia? From pop culture’s view to Rachel Star Withers, a diagnosed schizophrenic, view of herself to a leading mental health doctor and professor’s view. What are the actual symptoms? What is the difference between a hallucination and delusion? What is it like to experience one? How do you manage it? How is social media changing the way it is viewed? In this first episode of Inside Schizophrenia, Rachel and co-host Gabe Howard with special guest Dr. Ali Mattu explore this often misrepresented mental illness. Highlights From ‘Schizophrenia’ Episode [00:40] Would you th...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Inside Schizophrenia Peer Support Self-Help Source Type: blogs
Authors: Konstantakopoulos G Abstract There is now general agreement that lack of insight is not merely a fundamental aspect of delusions and hallucinations, or just a symptom of psychotic disorders but rather a multi-dimensional construct. Several different components of insight have been proposed and empirically examined during the last three decades, such as the ability to recognize that one has a mental illness, the capacity to relabel unusual mental events as pathological, the specific attribution of one's symptoms to having a mental illness, awareness of illness' consequences, and compliance with treatment.1 ...
Source: Psychiatriki - Category: Psychiatry Tags: Psychiatriki Source Type: research
3030Purpose: The purpose of this study is to evaluate altered regional histone deacetylase (HDAC) expression (density and distribution) in Alcohol Use Disorder (AUD) patients and age- and sex-matched healthy controls, using [11C]Martinostat as a PET radiotracer. We aim to measure HDAC density and distribution in the brain of AUD patients. We will test the hypothesis that HDAC enzyme expression is altered in AUD brains. We will take advantage of a combined PET/MRI system to collect simultaneous PET and structural MRI to obtain high-resolution spatial maps. This will address fundamental questions about chromatin modifying en...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Technologist Posters Source Type: research
We reported DEGs with a nominal p-value of 0.8. The network construction was created using blockwiseModules function for consideration of computer efficiency. The module detection criteria were as follows: minimum module size of 50, deepsplit of 4, and merge threshold of 0.25. The merged modules were then summarized with module eigengene (ME) correlations>0.75. MEs were defined by their first principal component and were labeled with different colors as module names in the Results section. After the modules were generated, we conducted different enrichment analysis to explore the functional interpretation of genes withi...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Albert Sanfeliu1, Karsten Hokamp2, Michael Gill1 and Daniela Tropea1,3*1Neuropsychiatric Genetics, Department of Psychiatry, School of Medicine, Trinity Translational Medicine Institute, St James Hospital, Dublin, Ireland2Department of Genetics, School of Genetics and Microbiology, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland3Department of Psychiatry, School of Medicine, Trinity College Institute for Neuroscience, Trinity College Dublin, Dublin, IrelandRett syndrome is a rare neuropsychiatric disorder with a wide symptomatology including impaired communication and movement, cardio-respiratory abno...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Chun Wu1†, Bevan E. Huang1, Guang Chen2, Timothy W. Lovenberg2, David J. Pocalyko1 and Xiang Yao3* 1Computational Sciences, Discovery Sciences, Janssen Research &Development, LLC, Spring House, PA, United States 2Neuroscience Therapeutic Area, Janssen Research &Development, LLC, La Jolla, CA, United States 3Computational Sciences, Discovery Sciences, Janssen Research &Development, LLC, La Jolla, CA, United States Transcriptomics technologies such as next-generation sequencing and microarray platforms provide exciting opportunities for improving diagnosis and treatment of complex diseases. Tra...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Conclusion Taken together, evidence from animal and human studies demonstrates that the brain detects levels of circulating nutrients and hormones and consequently organizes an outward response that contributes to the regulation of whole-body glucose homeostasis. However, there are major knowledge gaps about the exact nature of this response and its relative importance compared to peripheral processes. As we have seen, animal studies have provided an anatomical map of CNS glucose regulation and have identified important neurons and neural circuits involved. Additionally, the CNS sensing of key nutrients and hormones has b...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Alec L. W. Dick1, Khen Khermesh2, Evan Paul1, Fabian Stamp1, Erez Y. Levanon3 and Alon Chen1,4*1Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, Germany2CytoReason, Tel-Aviv, Israel3The Mina and Everard Goodman Faculty of LifeSciences, Bar-Ilan University, Ramat-Gan, Israel4Department of Neurobiology, Weizmann Institute of Science, Rehovot, IsraelAdenosine-to-inosine (A-to-I) RNA editing is a co-/posttranscriptional modification of double-stranded RNA, catalyzed by the adenosine deaminase acting on RNA (ADAR) family of enzymes, which results in recognition of inosine as guano...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
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