SB431542 inhibited cigarette smoke extract induced invasiveness of A549 cells via the TGF- β1/Smad2/MMP3 pathway.

In conclusion, CSE increased the invasiveness of A549 cells and its effects were abrogated by SB431542 and the TGF-β1/Smad2/MMP-3 pathway may have been involved. PMID: 29963124 [PubMed]

https://www.ncbi.nlm.nih.gov/pubmed/29963124?dopt=Abstract

Source: Oncology Letters - July 4, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research