ICSI treatment linked to increased prostate cancer risk

Men who undergo ICSI (intracytoplasmic sperm injection) are at greater risk of developing prostate cancer, according to a large study presented during the European Society of Human Reproduction and Embryology annual meeting.Medical Xpress
Source: Society for Endocrinology - Category: Endocrinology Source Type: news

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Conclusion BSI is a useful asset in stratification of patients with metastatic bone disease. It may also have a place in prediction of biochemical response.
Source: Nuclear Medicine Communications - Category: Nuclear Medicine Tags: ORIGINAL ARTICLES Source Type: research
Forced diuresis may improve readability of 2-(3-(1-carboxy-5-[(6-[18F]fluoro-pyridine-3-carbonyl)-amino]-pentyl)-ureido)-pentanedioic acid (18F-DCFPyL) PET/computed tomography (CT) by reducing focal ureteral activity. A total of 40 patients received furosemide simultaneously with 18F-DCFPyL (cohort 1) and 40 patients received furosemide 85 min after 18F-DCFPyL administration (cohort 2). The frequency of occurrence of activity depositions in ureters and halo artefacts near the kidneys and bladder was measured, as well as intensity of 18F-DCFPyL uptake in kidneys and bladder. At 120 min after injection of 18F-D...
Source: Nuclear Medicine Communications - Category: Nuclear Medicine Tags: TECHNICAL NOTE Source Type: research
Condition:   Prostate Cancer Intervention:   Diagnostic Test: Blood test: ClarityDX Prostate Sponsors:   Nanostics;   Alberta Prostate Cancer Research Initiative, APCaRI;   DynaLIFE Medical Laboratories;   Prostate Cencer Centre, Calgary;   Northern Alberta Urology Centre;   Alberta Cancer Foundation;   Alberta Innovates Health Solutions;   Motorcycle Ride for Dad;   Univers ity Hospital Foundation - The Kaye Fund Competition Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
(American Institute of Physics) Results reported in Biomicrofluidics promise a new way to detect prostate cancer through a simple device, which forces cell samples through channels less than 10 microns wide. When prostate cancer cells are forced through, the metastatic cells exhibit 'blebbing,' and the experiments show that highly metastatic prostate cancer cells are more likely to exhibit blebbing than normal cells or even less-metastatic cells are. The new device could be used to test large numbers of samples.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
Men with prostate cancer can avoid long waits to see a doctor by getting their test results online, sometimes even on the day their blood was taken. It is hoped the system will be rolled out more widely.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
ConclusionOur findings reinforce the importance of having access to tailored, timely and person-centred supported self-management care plans. Real-time monitoring data can provide helpful information to facilitate tailored recommendations for self-management.Implications for Cancer SurvivorsProstate cancer survivors can experience unmet supportive care needs which may increase men ’s demands to perform self-management of their condition. Future clinical intervention studies aimed at utilising the remote exchange of real-time data serves to optimise tailored supported self-management.
Source: Journal of Cancer Survivorship - Category: Cancer & Oncology Source Type: research
Sonodynamic therapy (SDT) is a minimally invasive anticancer therapy involving a chemical sonosensitizer and high-intensity focused ultrasound (HIFU). SDT enables the reduction of drug dose and HIFU irradiation power compared to those of conventional monotherapies. In our previous study, mouse models of colon and pancreatic cancer were used to confirm the effectiveness of SDT vs. drug-only or HIFU-only therapy. To validate its usefulness, we performed a clinical trial of SDT using an anticancer micelle (NC-6300) and our HIFU system in four pet dogs with spontaneous tumors, including chondrosarcoma, osteosarcoma, hepatocell...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
High-temperature requirement protease A4 (HtrA4) is a secretary serine protease whose expression is up-regulated in pre-eclampsia (PE) and hence is a possible biomarker of PE. It has also been altered in cancers such as glioblastoma, breast carcinoma, and prostate cancer making it an emerging therapeutic target. Among the human HtrAs, HtrA4 is the least characterized protease pertaining to both structure and its functions. Although the members of human HtrA family share a significant structural and functional conservation, subtle structural changes have been associated with certain distinct functional requirements. Therefo...
Source: Biochemical Journal - Category: Biochemistry Authors: Tags: Research Articles Source Type: research
ConclusionsAfrican ‐American prostate cancer patients' access to mpMRI is hindered more by barriers to care than White patients. Urology providers must consider these issues before using prostate mpMRI within their active surveillance pathways.
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
Authors: Wu Z, Huang W, Chen Y, Chen B, Liu R, Bai P, Xing J Abstract LINC01638 lncRNA is known as an oncogenic lncRNA in triple negative breast cancer. However, the role of LINC01638 lncRNA in other diseases is unknown. In the present study we observed that plasma levels of LINC01638 lncRNA and Notch1 were upregulated in prostate carcinoma patients comparing with healthy controls. LINC01638 lncRNA and Notch1 were positively correlated in prostate carcinoma patients but not in healthy controls. Upregulation of LINC01638 lncRNA distinguished prostate carcinoma patients from healthy controls. LINC01638 lncRNA overexp...
Source: Cancer Biomarkers - Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research
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