Metformin may help treatment of lung fibrosis

The diabetes drug could help reverse established lung fibrosis, a condition that currently lacks effective treatment options, according to a study inNature Medicine.Science Daily
Source: Society for Endocrinology - Category: Endocrinology Source Type: news

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In this study, we have systematically reviewed the relationships between KS and the cardiovascular system and the management of cardiovascular complication. In summary, patients with KS display increased cardiovascular risk profile, characterized by increased prevalence of metabolic alterations including dyslipidemia, diabetes mellitus (DM), and abnormalities in biomarkers of cardiovascular disease. KS subjects are characterized by subclinical abnormalities in endothelial function and in left ventricular (LV) systolic and diastolic function, which - when associated with chronotropic incompetence - may negatively influence ...
Source: Expert Review of Endocrinology and Metabolism - Category: Endocrinology Tags: Expert Rev Endocrinol Metab Source Type: research
Publication date: May 2019Source: Microchemical Journal, Volume 146Author(s): Chandra Shekhar Pundir, Mansi Malik, Reeti ChaudharyAbstractPyruvate (carboxylate anion of pyruvic acid) is an organic molecule, with a backbone of 3‑carbon atoms. Pyruvate is known to undergo several fates depending upon the organism under consideration. It is one of the only molecules involved in both synthesis and breakdown pathways, thereby making it a very busy molecule. Aberrant levels of this metabolite are known to cause several disorders like diabetes, cirrhosis, cardiovascular diseases and severe brain abnormalities. This is an attrac...
Source: Microchemical Journal - Category: Chemistry Source Type: research
The objective of this study was to evaluate machine-learning algorithms for accurately predicting short-term outcomes after ORIF for ankle fractures. The Nationwide Inpatient Sample and Nationwide Readmissions Database were queried for adult patients ≥18 years old who underwent ORIF of an ankle fracture during 2013 or 2014. Morbidity and mortality, length of stay>3 days, and 30-day all-cause readmission were the outcomes of interest. Two machine-learning models were created to identify patient and hospital characteristics associated with the 3 outcomes. The machine learning models were evaluated using confusion matri...
Source: The Journal of Foot and Ankle Surgery - Category: Orthopaedics Source Type: research
Publication date: Available online 23 February 2019Source: The Journal of Foot and Ankle SurgeryAuthor(s): Aditya V. Karhade, John Y. KwonABSTRACTThe foot and ankle surgery literature lacks an analysis of studies published in general medical journals. Studies published in general medical journals have high visibility and significant impact on decision making by medical practitioners and health care policy makers. Knowledge of the subject matter and methodologic characteristics of foot and ankle publications being read by general medical practitioners and the lay public is important to the practicing foot and ankle surgeon....
Source: The Journal of Foot and Ankle Surgery - Category: Orthopaedics Source Type: research
This study was registered with ClinicalTrials.gov, number NCT02424500.FindingsBetween Feb 2, 2015, and March 17, 2017, 236 patients were screened for eligibility, of whom 181 (77%) were enrolled and randomly assigned to the intervention (n=93) and control (n=88) groups. At baseline, mean HbA1c was 8·7% (SD 0·8; 72 mmol/mol [SD 8·8]) in the intervention group and 8·5% (SD 0·8; 69 mmol/mol [SD 8·8]) in the control group. The mean decrease in HbA1c from baseline to 6 months was 1·0% (SD 1·0; 11 mmol/mol [SD 11]) in the intervention group, and 0·3% (SD 0·9; ...
Source: The Lancet - Category: General Medicine Source Type: research
Publication date: Available online 22 February 2019Source: The Lancet Diabetes &EndocrinologyAuthor(s): Jaakko Tuomilehto
Source: The Lancet Diabetes and Endocrinology - Category: Endocrinology Source Type: research
Publication date: Available online 22 February 2019Source: The Lancet Diabetes &EndocrinologyAuthor(s): Maria Inês Schmidt, Paula A Bracco, John S Yudkin, Isabela M Bensenor, Rosane Härter Griep, Sandhi Maria Barreto, Cristina D Castilhos, Bruce B DuncanSummaryBackgroundThe burden of diabetes is increasing worldwide and diabetes can be prevented with intervention in people with impaired glucose tolerance (IGT). Intermediate hyperglycaemia defined without an oral glucose tolerance test as impaired fasting glucose (IFG) and high HbA1c are also used to characterise risk. We aimed to assess the prognostic proper...
Source: The Lancet Diabetes and Endocrinology - Category: Endocrinology Source Type: research
Publication date: Available online 22 February 2019Source: The Lancet Diabetes &EndocrinologyAuthor(s): Nayla Y León, Alejandra P Reyes, Vincent R HarleySummaryThe diagnosis and management of children born with ambiguous genitalia is challenging for clinicians. Such differences of sex development (DSDs) are congenital conditions in which chromosomal, gonadal, or anatomical sex is atypical. The aetiology of DSDs is very heterogenous and a precise diagnosis is essential for management of genetic, endocrine, surgical, reproductive, and psychosocial issues. In this Review, we outline a step-by-step approach, compile...
Source: The Lancet Diabetes and Endocrinology - Category: Endocrinology Source Type: research
Publication date: Available online 22 February 2019Source: Diabetes &Metabolic Syndrome: Clinical Research &ReviewsAuthor(s): Kulshrestha Himani, Gupta Vani, Supriya Mishra, Abbas Ali Mahdi, Awasthi Shelly
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
Publication date: Available online 22 February 2019Source: Diabetes &Metabolic Syndrome: Clinical Research &ReviewsAuthor(s): María M. Adeva-Andany, Julia Martínez-Rodríguez, Manuel González-Lucán, Carlos Fernández-Fernández, Elvira Castro-QuintelaAbstractDiabetes is a common metabolic disorder associated to elevated cardiovascular morbidity and mortality that is not explained by hyperglycemia or traditional cardiovascular risk factors such as smoking or hypercholesterolemia. Intensive glycemic control with insulin that achieves near-normal glycemia does not reduce s...
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
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