Dynamics of genome alterations in Crohn's disease associated colorectal carcinogenesis.

CONCLUSIONS: Molecular profiling of CD-CRCs and precursor lesions revealed an inflammation-associated landscape of genome alterations: 5p gains and TP53 mutations occurred early in tumor development. Detection of these aberrations in precursor lesions may help predicting disease progression and distinguishes CD-associated from sporadic colorectal neoplasia.
PMID: 29967250 [PubMed - as supplied by publisher]

Source: Clinical Cancer Research - July 2, 2018 Category: Cancer & Oncology Authors: Hirsch D, Wangsa D, Zhu YJ, Hu Y, Edelman DC, Meltzer PS, Heselmeyer-Haddad K, Ott C, Kienle P, Galata C, Horisberger K, Ried T, Gaiser T Tags: Clin Cancer Res Source Type: research