Sleep disordered breathing and fibroblast growth factor 23 in the Hispanic Community Health Study/Study of Latinos

Preclinical data suggest that hypoxia stimulates fibroblast growth factor 23 (FGF23) transcription and cleavage in osteocytes, resulting in elevated circulating c-terminal (cFGF23) levels but normal intact FGF23 (iFGF23) levels. We conducted a case-control study within the Hispanic Community Health Study/Study of Latinos to investigate whether sleep disordered breathing, as a model of hypoxemia, is independently associated with elevated cFGF23 levels in the general population and with elevated cFGF23 and iFGF23 levels in patients with chronic kidney disease (CKD), in whom FGF23 cleavage may be impaired.

Source: Bone - July 3, 2018 Category: Orthopaedics Authors: Rupal Mehta, Xuan Cai, Alexander Hodakowski, Bharat Thyagarajan, Donglin Zeng, Phyllis C. Zee, William Wohlgemuth, Susan Redline, James P. Lash, Myles Wolf, Tamara Isakova Tags: Full Length Article Source Type: research