My OCD story: evidence-based medicine to the rescue!

Karen Morley blogs about her experience of seeking help for her Obsessive-Compulsive Disorder (OCD) and how finding and using Cochrane evidence was a turning point. This blog post was originally published onEvidently Cochrane.Without knowing what it was, I had experienced episodes of Obsessive-Compulsive Disorder (OCD) since I was an adolescent, usually when I was particularly stressed. But it was when I was caring full time for my mother, who had multiple conditions including dementia, that I had an unusually distressing episode of contamination-related OCD. When I took to the internet I was amazed to discover that the obsessive checking, washing and acute, abnormal anxiety were symptoms of an illness with a name – and to recognize other symptoms from my past that I now realised were related to it.I read everything I could find …I read everything I could find. I knew I should be careful about my sources, but I read fairly indiscriminately from forums, charity websites and a variety of health websites – some sensible, others less so – and that was a mistake.I had a vague sense of stigma about mental illness and particularly about medication, so I was interested in talking therapies, especially Cognitive Behavioural Therapy (CBT) with Exposure and Response Prevention (ERP). What could I expect if I tried it? Unfortunately there were some out-of-date posts in which people described nightmare experiences: someone who had allegedly to sit for two hou...
Source: Cochrane News and Events - Category: Information Technology Authors: Source Type: news

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We report the human induced pluripotent stem cell line (iPSC) CSUASOi002-A, generated from urine-derived cells (UCs) from a 51-year-old female patient carrying compound heterozygous mutations (c.62_63delTinsGA and c.C892T) in the carbohydrate sulfotransferase 6 gene (CHST6). This patient was from a Chinese family of three siblings with macular corneal dystrophy (MCD). Patient UCs were reprogrammed by electroporation using the episomal plasmids (OCT4, SOX2, KLF4, L-MYC, LIN28 and shP53). The human MCD-UiPS cell line CSUASOi002-A retained the disease-associated genotype, while expressed pluripotent stem cell markers and coul...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
Publication date: Available online 16 October 2019Source: Journal of Psychiatric ResearchAuthor(s): Aline Ribeiro Borçoi, Suzanny Mendes de Oliveira, Joaquim Gasparini dos Santos, Mayara Mota de Oliveira, Ivana Alece Moreno Arantes, Flávia Vitorino Freitas, Júlia Assis Pinheiro, Juliana Krüger Arpini, Ester Ribeiro Cunha, Anderson Barros Archanjo, Aricia Leone Evangelista Monteiro de Assis, Bruna Pereira Sorroche, Lídia Maria Rebolho Batista Arantes, Elizeu Borloti, Adriana Madeira Álvares-da-SilvaAbstractObjectiveThe aim of this study was to verify determinant factors for depression...
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research
This report therefore uses quality assurance data looking into whether sensory processing sensitivity (SPS) affects treatment outcome among patients with OCD. SPS is a personality trait regarding heightened levels of emotional reactivity and deeper cognitive processing of emotional stimuli. Patients received concentrated exposure treatment for obsessive-compulsive disorder (OCD). They were assessed with one of the most widely used questionnaires for measuring SPS, the Highly Sensitive Person Scale (HSPS). Analyses tested whether HSPS scores at pre-treatment affected treatment outcome, and if sensitivity changed from pre-to...
Source: Journal of Obsessive Compulsive and Related Disorders - Category: Psychiatry Source Type: research
In this study, antidepressive efficacy of white ginseng (Panax gingseng Meyer, WG) was evaluated in stressed ovariectomized rats. Female Sprague Dawley rats were ovariectomized and repeatedly restraint stressed for 2 weeks (2h/day). Thirty minutes before restraint stress, rats were administered saline (control), WG 200 mg/kg (p.o.), WG 400 mg/kg (p.o.), or fluoxetine (PC, 10 mg/kg, i.p.). Tail suspension test (TST) and forced swimming test (FST) were performed to assess antidepressant effect of WG. After behavioral tests, levels of serum corticosterone (CORT) and hippocampal 5-HT were measured. Significant decrease of immo...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Conclusions: Stress should be considered among other problems related to ADHD. Psychoeducation about stress, stress managing techniques and coaching should be included in the treatment of adolescents with ADHD. PMID: 31613179 [PubMed - as supplied by publisher]
Source: Nordic Journal of Psychiatry - Category: Psychiatry Tags: Nord J Psychiatry Source Type: research
Source: The Doctors Lounge - Psychiatry - Category: Psychiatry Tags: Cardiology, Psychiatry, Sports Medicine, News, Source Type: news
Publication date: Available online 15 October 2019Source: Molecular and Cellular ProbesAuthor(s): Danning Lou, Jun Wang, Xiaohang WangAbstractMajor depressive disorder (MDD) is one of the most prevalent psychiatric disorders worldwide and a major public health concern that is associated with grave consequences. Systemic complexity and feedback processes among diverse drivers of the depression disorder contribute to the considerable variation in responses to the treatment of depression. Dysfunctional microRNA (miRNA) is involved in MDD. miR-124 is enriched in the brain and may be critical in neuronal differentiation. Previo...
Source: Molecular and Cellular Probes - Category: Molecular Biology Source Type: research
[This Day] Parents, teachers and school managers recently converged on the Main Auditorium, Lagos Business School for the second edition of the Olashore International School mental wellness programme, aimed at promoting awareness of the incidence of suicide among youths in the country and provide guides to tackle the challenges.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
Conclusions: Six commonly used anxiety scales demonstrate similar responsiveness, and estimated MIDs can be used to gauge anxiety change in clinical research and practice.
Source: Medical Care - Category: Health Management Tags: Original Articles Source Type: research
BACKGROUND: Identifying neuropsychiatric disorders is essential for prompt treatment to reduce morbidity. Among these disorders, anxiety and depression have been frequently associated with Parkinson disease (PD), particularly among elderly population. ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
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