Inhibition of the acetyltransferase NAT10 normalizes progeric and aging cells by rebalancing the Transportin-1 nuclear import pathway

This study identifies a nuclear import pathway affected in aging and underscores the potential for NAT10 inhibition as a possible therapeutic strategy for HGPS and perhaps also for pathologies associated with normal aging.

Source: Signal Transduction Knowledge Environment - July 3, 2018 Category: Science Authors: Larrieu, D., Vire, E., Robson, S., Breusegem, S. Y., Kouzarides, T., Jackson, S. P. Tags: STKE Research Articles Source Type: news