Research Reveals Immunotherapy More Effective in Men

For mesothelioma patients, immunotherapy is mostly available through clinical trials at this time. Immunotherapy is a relatively new way to treat cancer, and doctors still are learning who will respond best to these novel therapies. Newly released medical research has found men seem to respond better to immunotherapy than women. But this doesn’t mean immunotherapy is off the table for women with mesothelioma. You should learn all you can about how immunotherapy works, why it may or may not be right for you and how you can best prepare yourself if you decide an immunotherapy clinical trial is right for you. Thorough Review of Immunotherapy Research In June 2018, Lancet Oncology published a systematic review and meta-analysis of high-quality immunotherapy clinical trials. A systematic review answers a defined research question by carefully considering the highest quality evidence about the question of interest. In the Lancet Oncology report, the question of interest was, “Is there a difference in how well men and women with cancer respond to a type of immunotherapy known as immune checkpoint inhibitors?” A meta-analysis uses statistical methods to combine the data from the studies included in the review. By combining the studies together, researchers end up with a larger pool of people to analyze. Having a larger study sample improves a researcher’s ability to uncover differences between the groups. In the Lancet Oncology paper, the groups being compare...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news

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In conclusion, these data indicate that KIF23 is a potential therapeutic target for gastric cancer treatment. PMID: 31007778 [PubMed - in process]
Source: Disease Markers - Category: Laboratory Medicine Tags: Dis Markers Source Type: research
Authors: Mitra SR, Tan PY, Amini F Abstract Gene-diet interaction studies have reported that individual variations in phenotypic traits may be due to variations in individual diet. Our study aimed to evaluate (i) the association of ADRB2 rs1042713 with obesity and obesity-related metabolic parameters and (ii) the effect of dietary nutrients on these associations in Malaysian adults. ADRB2 genotyping, dietary, physical activity, anthropometric, and biochemical data were collected from 79 obese and 99 nonobese individuals. Logistic regression revealed no association between ADRB2 rs1042713 and obesity (p=0.725). Howe...
Source: Journal of Nutrition and Metabolism - Category: Nutrition Tags: J Nutr Metab Source Type: research
Publication date: Available online 22 April 2019Source: Life Sciences in Space ResearchAuthor(s): L. Walsh, U. Schneider, A. Fogtman, C. Kausch, S. McKenna-Lawlor, L. Narici, J. Ngo-Anh, G. Reitz, L. Sabatier, G. Santin, L. Sihver, U. Straube, U. Weber, M. DuranteAbstractThe European Space Agency (ESA) is currently expanding its efforts in identifying requirements and promoting research towards optimizing radiation protection of astronauts. Space agencies use common limits for tissue (deterministic) effects on the International Space Station. However, the agencies have in place different career radiation exposure limits (f...
Source: Life Sciences in Space Research - Category: Biology Source Type: research
Publication date: Available online 23 April 2019Source: Life SciencesAuthor(s): Muzammal Hussain, Dickson Adah, Muqddas Tariq, Yongzhi Lu, Jiancun Zhang, Jinsong LiuAbstractThe tumor microenvironment comprises stromal and tumor cells which interact with each other through complex cross-talks that are mediated by a variety of growth factors, cytokines, and chemokines. The chemokine ligand 13 (CXCL13) and its chemokine receptor 5 (CXCR5) are among the key chemotactic factors which play crucial roles in deriving cancer cell biology. CXCL13/CXCR5 signaling axis makes pivotal contributions to the development and progression of ...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 22 April 2019Source: Life SciencesAuthor(s): Patricia Leticia Trindade, Elaine dos Ramos Soares, Elisa Bernardes Monteiro, Ângela Castro Resende, Nathalia Moura-Nunes, Vanessa Souza-Mello, Danielly Cristiny Ferraz, Julio Beltrame DalepraneAbstractBody adiposity is an important risk factor for the development of chronic non-transmissible diseases. Studies on the process of adipogenesis have been extensively performed in vivo and in vitro models to describe the molecular and cellular bases of adipose tissue development and the effect of natural products in this process. The aça...
Source: Life Sciences - Category: Biology Source Type: research
In this study, the antifungal activity of base analogues, 5-flucytosine (5-FC) and 5-fluorouracil (5-FU), was tested against planktonic cells as well as against mature biofilm.MethodsTests were performed according the EUCAST methodology. Antibiofilm effectiveness of tested drugs was determined by the crystal violet staining method. The cytotoxicity assays was performed according to the ISO 10993-5 norm.Results5-FC and 5-FU were effective against fifteen fluconazole resistant Candida glabrata strains with an average minimal inhibitory concentration (MIC) of 0.152 mg/L and 0.39 mg/L, respectively. Folinic acid (fol...
Source: Journal of Medical Mycology - Category: Biology Source Type: research
In conclusion, results of the present study show that feeding common carp with a diet containing 1 g/kg OLE over a period of 60 days might be adequate to improve fish immune parameters, and survival rate against E. tarda. Therefore, OLE can be used as a dietary additive to prevent E. tarda in common carp.
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
Publication date: Available online 22 April 2019Source: Biological ControlAuthor(s): C. Rusin, A. Di Francesco, M. Di Foggia, S. D'Aquino, A. Rombolà, V. Tugnoli, R. Vasconcelos Botelho, E. BaraldiAbstractAureobasidium pullulans strains L1 and L8 were used as an alternative strategy against Neofusicoccum parvum, pathogen of apple wood and fruit. Both strains displayed a great ability to reduce pathogen conidia germination of almost 50% and totally stop its sporification in wood of ‘Gala’ and ‘Fuji’ apple cultivars. In addition, by in vitro tests the antagonistic activity displayed by non-vola...
Source: Biological Control - Category: Biology Source Type: research
Publication date: Available online 22 April 2019Source: Colloids and Surfaces A: Physicochemical and Engineering AspectsAuthor(s): Shengtao Wang, Jingtao Li, Zhou Ye, Jieling Li, Anhe Wang, Jing Hu, Shuo Bai, Jian YinAbstractHerein, an amphipathic polymeric photosensitizer, designated as PEGylated distyryl boron dipyrromethenes with real-time tracing property, is synthesized as a kind of multifunctional carrier to load drugs for combined photodynamic-chemo therapy. The hydrophilic PEG side chains on the carriers prolong its blood circulation time and the self-assembly capacity of PEGylated distyryl boron dipyrromethenes ef...
Source: Colloids and Surfaces A: Physicochemical and Engineering Aspects - Category: Chemistry Source Type: research
Publication date: Available online 22 April 2019Source: Colloids and Surfaces A: Physicochemical and Engineering AspectsAuthor(s): Srinivasan Ayyanaar, Mookkandi Palsamy Kesavan, Gandhi Sivaraman, Balaji Maddiboyina, Jamespandi Annaraj, Jegathalaprathaban Rajesh, Gurusamy RajagopalAbstractPoly(D, L-lactide-co-glycolic acid) (PLGA) based magnetic microspheres (MMS) hold immense potential for reaching the target of controlled and specific drug delivery site with low toxicity. Herein, we have synthesized the biodegradable PLGA microspheres (MS) containing magnetic iron oxide nanoparticles (MIONPs) by the emulsion solvent evap...
Source: Colloids and Surfaces A: Physicochemical and Engineering Aspects - Category: Chemistry Source Type: research
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