Research Reveals Immunotherapy More Effective in Men

For mesothelioma patients, immunotherapy is mostly available through clinical trials at this time. Immunotherapy is a relatively new way to treat cancer, and doctors still are learning who will respond best to these novel therapies. Newly released medical research has found men seem to respond better to immunotherapy than women. But this doesn’t mean immunotherapy is off the table for women with mesothelioma. You should learn all you can about how immunotherapy works, why it may or may not be right for you and how you can best prepare yourself if you decide an immunotherapy clinical trial is right for you. Thorough Review of Immunotherapy Research In June 2018, Lancet Oncology published a systematic review and meta-analysis of high-quality immunotherapy clinical trials. A systematic review answers a defined research question by carefully considering the highest quality evidence about the question of interest. In the Lancet Oncology report, the question of interest was, “Is there a difference in how well men and women with cancer respond to a type of immunotherapy known as immune checkpoint inhibitors?” A meta-analysis uses statistical methods to combine the data from the studies included in the review. By combining the studies together, researchers end up with a larger pool of people to analyze. Having a larger study sample improves a researcher’s ability to uncover differences between the groups. In the Lancet Oncology paper, the groups being compare...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news

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The objectives of the current review are to comprehensively evaluate (1) the potential role of orexins in the pathophysiology of major depressive disorders (MDD) and (2) the orexin system as a novel target in the treatment of MDD. Dysfunction of the sleep-wake cycle is observed as a central feature of MDD pathophysiology. Orexin system disturbances produce sleep-wake dysfunction, as observed in MDD. Orexin antagonists have been shown to treat insomnia effectively without disrupting normal sleep architecture in both preclinical (e.g., animal models) and clinical studies. Orexin antagonists are generally safe, well-tolerated...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - Category: Psychiatry Source Type: research
ConclusionsOur small-scale experimental study, in which PanoptiqTM was used in the diagnosis of cases that were difficult to diagnose definitively by breast FNA, revealed a positive CB score by every reviewer and the representative diagnosis showed a significant CB. The study suggested that PanoptiqTM could be used for cytopathology consultation.
Source: Journal of the American Society of Cytopathology - Category: Cytology Source Type: research
Publication date: Available online 18 December 2018Source: Journal of Neuroscience MethodsAuthor(s): Sara J. Aton, Giuseppe Di Giovanni, Nathalie Leresche
Source: Journal of Neuroscience Methods - Category: Neuroscience Source Type: research
ConclusionsThe comparison of spectral properties of binary event signals and permutated event signals is effective in detecting slow oscillatory phenomena.
Source: Journal of Neuroscience Methods - Category: Neuroscience Source Type: research
Publication date: Available online 17 December 2018Source: Journal of Neuroscience MethodsAuthor(s): Armand Mensen, Andrea Pigorini, Laura Facchin, Cornelia Schöne, Sasha D'Ambrosio, Jasmine Jendoubi, Valeria Jaramillo, Kathrin Studer, Aleksandra Eberhard-Moscicka, Simone Sarasso, Antoine Adamantidis, René Müri, Reto Huber, Marcello Massimini, Claudio BassettiAbstractOur own experiences with disturbances to sleep demonstrate its crucial role in the recovery of cognitive functions. This importance is likely enhanced in the recovery from stroke; both in terms of its physiology and cognitive abilities. Decade...
Source: Journal of Neuroscience Methods - Category: Neuroscience Source Type: research
Authors: Maia Palhano AC, Kim LJ, Moreira GA, Santos Coelho FM, Tufik S, Levy Andersen M Abstract Narcolepsy is a sleep disorder characterized by excessive daytime sleepiness, cataplexy, sleep paralysis and hypnagogic and hypnopompic hallucinations. The onset of the symptoms usually occurs in childhood, and previous studies have reported an association between narcolepsy and other endocrine diseases in the pediatric population, such as obesity and precocious puberty. The incidence of overweight or obesity ranges from 25% to 74% in patients with narcolepsy type I, while precocious puberty is present in 17% of childr...
Source: Pediatric Endocrinology Reviews - Category: Endocrinology Tags: Pediatr Endocrinol Rev Source Type: research
CONCLUSIONS: Weight loss combined with a healthy lifestyle was shown to be very beneficial for patients with moderate to severe disease with a significant reduction of the Psoriasis Area and Severity Index (PASI) score. Currently, oral vitamin D supplementation for prevention or treatment of psoriasis in adults with normal vitamin D levels is not recommended; however, psoriasis patients with a deficit in plasma vitamin D levels are advised to complement with oral supplements to prevent psoriasis-related comorbidities. Instead of zinc, selenium, and omega 3 supplements have been proven beneficial for psoriasis patients. Amo...
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Authors: Liu B, Yang XF, Liang XP, Wang L, Shao MM, Han WX, Wu YH Abstract OBJECTIVE: To explore the expressions of miR-132 in patients with chronic hepatitis B, posthepatitic cirrhosis and hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC), and to investigate its possible mechanism affecting the function of the body. PATIENTS AND METHODS: Among 125 patients with HBV, there were 44 cases of chronic hepatitis, 42 cases of liver cirrhosis and 39 cases of liver cancer. Their liver function and HBV-deoxyribonucleic acid (HBV-DNA) viral load as well as the expressions of micro ribonucleic acid-132 (miR-1...
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
CONCLUSIONS: Our findings provide novel insights into the role of miR-3196 in breast cell proliferation and apoptosis. Meanwhile, this study suggests that miR-3196 can serve as a potential biomarker and therapeutic target for breast cancer. PMID: 30556879 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
CONCLUSIONS: We showed that miR-1179 was a tumor suppressor that may serve as a novel potential prognostic biomarker or molecular therapeutic target for BC. PMID: 30556878 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
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