Impact of body mass index on female fertility and ART outcomes.

Impact of body mass index on female fertility and ART outcomes. Panminerva Med. 2018 Jun 28;: Authors: Imterat M, Agarwal A, Esteves SC, Meyer J, Harlev A Abstract As the global mean body mass index (BMI) is on the rise, the importance of understanding exactly how female fertility is impacted by once outlier BMI values, becomes ever more important. Studies have implicated abnormal BMI impacts the female reproductive system by contributing to anovulation, irregular menses, adverse oocyte quality, endometrial alterations, and hormonal imbalances that ultimately result in female infertility, which could complicate natural conception efforts and request considering assisted reproductive technology (ART) in such couples. With an increase in the demand for ART, it is crucial to understand what factors can be altered by the female BMI, in order to maximize the opportunity for successful pregnancy. The current study aimed to review the information about the effect of BMI on the female fertility and ART outcomes. The complex nature of the female reproductive system leaves space for multiple factors to adversely affect its processes. Imbalances in the hypothalamus-pituitary-ovarian axis can impede efforts for couples to conceive. Leptin and estrogen are two hormones that have been implicated in regulating BMI as well as reproductive physiology. Lifestyle modifications prior to, and during ART have shown promise enhancing fecundity. The intrica...
Source: Panminerva Medica - Category: General Medicine Tags: Panminerva Med Source Type: research