Roles and mechanisms of leptin in osteogenic stimulation in cervical ossification of the posterior longitudinal ligament

Hyperleptinemia is a common feature of obese people, and leptin, an adipocyte-derived cytokine, is believed to be an important factor in the pathogenesis of cervical ossification of the posterior longitudinal ...
Source: Journal of Orthopaedic Surgery and Research - Category: Orthopaedics Authors: Tags: Research article Source Type: research

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In this study we investigated these questions using eye-tracking and a two alternative forced food-choice task after measuring subjective values (attitude extremity) and their accompanying accessibility, certainty, and stability. Understanding this basic decision-making process is key if we are to gain insight on how to combat societal problems like obesity and other issues related to diet. We found that participants allocated more attention to items with lower attitude accessibility, but tended to choose items with higher attitude accessibility. Higher attitude certainty and stability had no effects on attention, but led ...
Source: Journal of Experimental Social Psychology - Category: Psychiatry & Psychology Source Type: research
Publication date: November 2019Source: Journal of Functional Foods, Volume 62Author(s): Ruiyu Wu, Xin Tang, Xincong Kang, Yushuang Luo, Lei Wang, Jian Li, Xiyang Wu, Dongbo LiuAbstractNumerous microbiotas, which play important roles in health, inhabit the human gut. A traditional Chinese medicine dietary therapy (TCMDT) diet, consisted of whole grains and traditional Chinese medicines, is traditionally used to lessen hyperglycemia and reduce obesity. The Simulator of the human intestinal microbial ecosystem (SHIME) was used for studying the effect of the TCMDT diet on gut microbiota and short chain fatty acids. The TCMDT d...
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
Publication date: Available online 14 September 2019Source: Journal of the Formosan Medical AssociationAuthor(s): Chih-Wei Sung, Chien-Hua Huang, Wen-Jone Chen, Wei-Tien Chang, Chih-Hung Wang, Yen-Wen Wu, Wei-Ting Chen, Jia-How Chang, Min-Shan TsaiBackgroundThe role of body mass index (BMI) in clinical outcomes in patients resuscitated from cardiac arrest (CA) has recently drawn attention. We evaluated the effect of BMI on the prognosis of patients successfully resuscitated from cardiogenic arrest.MethodsThis retrospective cohort study included 273 non-traumatic adult cardiogenic arrest survivors receiving coronary angiogr...
Source: Journal of the Formosan Medical Association - Category: General Medicine Source Type: research
A new report shows that nine states have adult obesity rates that equal or exceed 35%. Here is the breakdown by state.
Source: Healthcare News - Category: Pharmaceuticals Authors: Source Type: news
Publication date: September 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 9Author(s): Yao-Hao XU, Wei LI, Yong RAO, Zhi-Shu HUANG, Sheng YINAbstractBioassay-guided fractionation of an ethanolic extract of Ochrosia borbonica led to the isolation of two known pyridocarbazole alkaloids, ellipticine (1) and 9-methoxyellipticine (2), and six known monoterpenoid indole alkaloids (3–8). Lipid-lowering assay in 3T3-L1 cell model revealed that 1 and 2 could significantly inhibit the lipid droplet formation (EC50 = 0.41 and 0.92 μmol·L−1, respectively) and lower triglyceride levels by 50%&n...
Source: Chinese Journal of Natural Medicines - Category: Complementary Medicine Source Type: research
Authors: Health Promotion and Chronic Disease Prevention in Canada editorial staff Abstract This corrigendum is being published to correct a number of errors and imprecisions, on pages 437-442, of the following article:Rao DP, Patel P, Roberts KC, Thompson W. Obesity and healthy aging: social, functional and mental well-being among older Canadians. Health Promot Chronic Dis Prev Can. 2018;38(12):437-44. doi: 10.24095/hpcdp.38.12.01. PMID: 31517470 [PubMed - in process]
Source: Health Promotion and Chronic Disease Prevention in Canada - Category: International Medicine & Public Health Tags: Health Promot Chronic Dis Prev Can Source Type: research
Conclusion: Overweight and obese individuals have lower serum folate concentrations when compared with individuals with normal weight. It is explained by increased use of folic acid, urinary excretion, dilution of blood volume, different levels in different tissues and changes in the endocrine functions of folate. Individuals with higher Body Mass Indexes have less supplement use, unhealthier diets and donot consume sufficient vegetables and fruits, all of which can affect decrease in folate levels. Furthermore, adiposity may affect folate absorption by intestinal epithelium. PMID: 31512572 [PubMed - as supplied by publisher]
Source: International Journal for Vitamin and Nutrition Research - Category: Nutrition Tags: Int J Vitam Nutr Res Source Type: research
Abstract High fluoride exposure has been related to harmful health effects, but the impacts of low-to-moderate fluoride on child growth and obesity-related outcomes remain unclear. We performed a large-scale cross-sectional study to examine the association between low-to-moderate fluoride in drinking water and anthropometric measures among Chinese school-age children. We recruited 2430 resident children 7-13 years of age, randomly from low-to-moderate fluorosis areas of Baodi District in Tianjin, China. We analyzed the fluoride contents in drinking water and urine samples using the national standardized ion sele...
Source: Ecotoxicology and Environmental Safety - Category: Environmental Health Authors: Tags: Ecotoxicol Environ Saf Source Type: research
Authors: Zhong B, Ma S, Wang DH Abstract BACKGROUND: Activation of transient receptor potential vanilloid subtype 1 (TRPV1) channels protects the heart from ischemia/reperfusion (I/R) injury through releasing calcitonin gene-related peptide (CGRP) and substance P (SP). The current study aimed to study the cardioprotective effects of TRPV1 in obesity. METHODS: TRPV1 gene knockout (TRPV1-/-) and wild-type (WT) mice were fed a high-fat diet (HFD) or a control diet or for 20 weeks, and then the hearts were collected for I/R injury ex vivo. The hearts were mounted on a Langendorff apparatus and subjected to ischemia...
Source: Cardiovascular and Hematological Disorders Drug Targets - Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research
ConclusionGinsenoside Mc1 decreases oxidative stress and increases cell viability in H9c2 cells and the heart tissue isolated from HFD-fed mice via an AMPK-dependent mechanism, suggesting its potential as a novel therapeutic agent for oxidative stress–related cardiac diseases.
Source: Journal of Ginseng Research - Category: Complementary Medicine Source Type: research
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