The application value of MRI in the diagnosis of subclinical inflammation in patients with rheumatoid arthritis in remission

To explore the value of MRI in the diagnosis of subclinical inflammation in patients with early rheumatoid arthritis (RA) in remission and to predict the radiographic progression.
Source: Journal of Orthopaedic Surgery and Research - Category: Orthopaedics Authors: Tags: Research article Source Type: research

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Publication date: Available online 20 September 2019Source: Reumatología Clínica (English Edition)Author(s): Susana Aideé González-Chávez, César Pacheco-Tena, Rosa María Campos Torres, Celia María Quiñonez-Flores, Greta Reyes-Cordero, Teresita de Jesús Caraveo FrescasAbstractObjectiveTo characterize the orofacial abnormalities in patients with rheumatoid arthritis (RA) and compare them with those in a reference population.MethodsThe study included 30 RA patients and 30 consecutive patients in an odontology clinic in whom RA was ruled out. Patients underw...
Source: Reumatologia Clinica - Category: Rheumatology Source Type: research
CONCLUSION: DAS28 score and disease activity are strong indicators of TMJ affection in RA patients when compared to RF and ACCP. ACCP is a better indicator of changes in condylar measurements than TMJ osteoarthritic changes. While RF is the least efficient indicator of TMJ involvement in RA patients. PMID: 31530023 [PubMed - as supplied by publisher]
Source: Dentomaxillofacial Radiology - Category: Radiology Tags: Dentomaxillofac Radiol Source Type: research
This article is retrospective consecutive series of 110 valgus knees using CR implants with a minimum 2-year follow-up. Deformity correction was achieved using stepwise sequential soft tissue releases (iliotibial band, popliteus tendon, lateral collateral release through sliver femoral condylar osteotomy). Demographic data, range of movement, and degrees of deformity were collected. The Oxford Knee Score (OKS) was used as patients' reported outcome measure at final follow-up. One-hundred and four patients (110 knees) were included (87 females/17 males) with mean age of 68.7 years. Primary diagnosis was osteoarthritis in 85...
Source: Journal of Knee Surgery - Category: Orthopaedics Authors: Tags: Original Article Source Type: research
Conclusions: PET/CT images provide unique quantitative information that cannot be obtained from any other imaging modalities.
Source: Quintessence International - Category: Dentistry Source Type: research
CONCLUSION: The RA-BIODAM prospective study succeeded in generating an extensive list of clinical, imaging (2343 radiographs), and biosample (4638 sera) resources that will be made available to expedite the identification and validation of biomarkers for radiographic damage endpoints. PMID: 31474600 [PubMed - as supplied by publisher]
Source: J Rheumatol - Category: Rheumatology Authors: Tags: J Rheumatol Source Type: research
CONCLUSION: FM0807 exerts its therapeutic effects on RA by inhibiting cartilage degeneration. FM0807 treatment might be an effective therapeutic approach for RA. PMID: 31431516 [PubMed - as supplied by publisher]
Source: Bioscience Reports - Category: Biomedical Science Authors: Tags: Biosci Rep Source Type: research
ConclusionAbnormalities were identified in 79% of chest radiographs in RA patients. Sixty-six percent of these were not reported. Clinicians need to be aware of the need to check for abnormalities.Key Points•RA patients have a high prevalence of CXR abnormalities.•Many of these are of clinical significance.•Age, being male, and seropositivity were associated with lung abnormalities.
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
AbstractBCD-055 is a biosimilar of innovator infliximab (IFX). Here we present the 54-week results from phase 3 clinical study in patients with rheumatoid arthritis (RA). The aim of this study was to demonstrate the equivalent efficacy and safety of BCD-055 and IFX in patients with active rheumatoid arthritis. 426 adults with active RA were enrolled. Patients were randomized into 2 study arms in 2:1 ratio to receive BCD-055 or IFX innovator in dose of 3  mg/kg at week 0, 2, 6 and then every 8 weeks up to week 54. Primary efficacy endpoint was the rate of American College of Rheumatology (ACR) 20 response at week ...
Source: Rheumatology International - Category: Rheumatology Source Type: research
ConclusionThe cost per responder and patient in remission favoured abatacept in patients with seropositive, erosive early RA across all the countries. In this patient population, the use of abatacept instead of adalimumab can lead to lower costs in the US, Germany, Spain, and Canada.
Source: Rheumatology International - Category: Rheumatology Source Type: research
Authors: Direito R, Rocha J, Serra AT, Fernandes A, Freitas M, Fernandes E, Pinto R, Bronze R, Sepodes B, Figueira ME Abstract Persimmon (Diospyros kaki L.) fruits are used in traditional medicine largely due to their claimed beneficial effects on human health. The aim of this work was to evaluate the anti-inflammatory activity of a persimmon extract in rats with collagen-induced arthritis (CIA). CIA was induced in Wistar rats through an intradermal injection of an emulsion of bovine type II collagen (CII) in complete Freund's adjuvant (FCA). Macroscopic evidence of CIA first appeared as periarticular erythema and ...
Source: Journal of Dietary Supplements - Category: Nutrition Tags: J Diet Suppl Source Type: research
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