Study Explores the Molecular Basis of Chronic Pain Following Nerve Injury

Researchers identifiy a key molecule, dual leucine zipper kinase (DLK), that controls pathways leading to chronic neuropathic pain following nerve injury.
Source: NCCAM Featured Content - Category: Complementary Medicine Authors: Source Type: news

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Publication date: Available online 24 May 2019Source: Best Practice &Research Clinical GastroenterologyAuthor(s): Per M. HellströmAbstractIrritable bowel syndrome (IBS) is a chronic gastrointestinal symptom complex defined by abdominal pain and disturbed bowel habits over 3 months within a period of 6 months, in absence of any identifiable organic pathology. Over the years, speculations of the pathophysiology of IBS has moved from elusive central nervous symptoms impinging on psychosomatic disease, to objective signs of intestinal fermentation with abdominal bloating and intestinal dysmotility. The specific subgro...
Source: Best Practice and Research Clinical Gastroenterology - Category: Gastroenterology Source Type: research
We present the rare case of a 47-year-old male long-distance runner who was referred to our hospital with a longstanding pain in his left calf. Clinical history, as well as ultrasound and magnetic resonance imaging scans, showed an accessory peroneal muscle. This muscle was identified as a peroneus quartus muscle. On ultrasound, controlled intracompartmental pressure measurement, a chronic peroneal compartment syndrome, was diagnosed. We performed an endoscopic-assisted fasciotomy of the peroneal compartment. This resolved the patient's symptoms completely and allowed the runner to return to competition shortly after the surgery.
Source: The Journal of Foot and Ankle Surgery - Category: Orthopaedics Source Type: research
We report about hirudotherapy in a patient with chronic complex regional pain syndrome (CRPS) in the right hand. CRPS is a multifactorial disease associated with disabling pain as well as sensory and motor deficits. The optimal therapeutic management is based on personalized multimodal treatment approaches; however, hirudotherapy has not been described in the available literature. To date, we have completed five medicinal leech treatments. Altogether, hirudotherapy led to rapid and substantial relief of symptoms, especially with respect to pain intensity ratings and skin temperature asymmetries. In Addition, the patient&rs...
Source: Journal of Integrative Medicine - Category: Complementary Medicine Source Type: research
ConclusionHere we show that in twelve clinical cases, the cartilage was observed successfully regenerating and covering the defect region in knees after the intra-articular injection with adipose-derived mesenchymal stem cells (MSCs), and the treatment highly improves the symptoms of osteoarthritis. Basically, the adipose-derived MSCs from the patients are cultured and expanded to a specific amount with the optimized stem cell culture medium, the HELENE MEDIUM. After that, the cultured MSCs are directly injected into the injured knee joints of patients. The cartilage has gradually regenerated and been monitored by MRI phot...
Source: Cytotherapy - Category: Cytology Source Type: research
Condition:   Pain, Chronic Interventions:   Behavioral: Daily Self-Monitoring Surveys + Contingency Management;   Behavioral: Daily Self-Monitoring Surveys Sponsor:   Virginia Commonwealth University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
The objective is to observe if it could be possible to use the apoptosis test to distinguish different aetiologies in chronic pelvic pain syndrome (CPPS). A prospective study was done, 106 patients, 57 had previously been diagnosed with urological chronic pelvic pain (UCPP)/interstitial cystitis (IC) and 49 patients with gynaecological chronic pelvic pain (GCPP). Neoplastic cells cultures were exposed to the urine of patients with UCPP/IC and patients with GCPP. The urine ability to provoque apoptosis on them was analysed. The apoptosis degree was measured by quantifying the percentage of cells in phase subG0, determined b...
Source: Urologia Internationalis - Category: Urology & Nephrology Source Type: research
Condition:   Pain, Chronic Interventions:   Behavioral: Daily Self-Monitoring Surveys + Contingency Management;   Behavioral: Daily Self-Monitoring Surveys Sponsor:   Virginia Commonwealth University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Title: WHO Opioid Guidelines Too Lax: U.S. LawmakersCategory: Health NewsCreated: 5/23/2019 12:00:00 AMLast Editorial Review: 5/24/2019 12:00:00 AM
Source: MedicineNet Chronic Pain General - Category: Anesthesiology Source Type: news
Chronic low back pain is potentially disabling for older adults, and exercise is considered the best treatment. The Pilates method and aerobic exercises have been proven to be effective in pain and function im...
Source: BMC Musculoskeletal Disorders - Category: Orthopaedics Authors: Tags: Study protocol Source Type: research
There exists limited data on the association between unhealthy body weight and chronic pain, and whether this association is explained by frailty status of older adults.
Source: BMC Geriatrics - Category: Geriatrics Authors: Tags: Research article Source Type: research
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