Cardiovascular Effects Mediated by Imidazoline Drugs: an Update.

Cardiovascular Effects Mediated by Imidazoline Drugs: an Update. Cardiovasc Hematol Disord Drug Targets. 2018 Jun 29;: Authors: Cobos-Puc LE, Aguayo-Morales H Abstract Clonidine is a centrally acting antihypertensive drug. Hypotensive effect of clonidine is mediated mainly by central a2-adrenoceptors and/or imidazoline receptors located in a complex network of the brainstem. Unfortunately, clonidine produces side effects such as sedation, mouth dry, and depression. Moxonidine and rilmenidine, compounds of the second generation of imidazoline drugs, with fewer side effects, display a higher affinity for the imidazoline receptors compared with a2-adrenoceptors. The antihypertensive action of these drugs is due to inhibition of the sympathetic outflow primarily through central I1-imidazoline receptors in the RVLM, although others anatomical sites and mechanisms/receptors are involved. Agmatine is regarded as the endogenous ligand for imidazoline receptors. This amine modulates the cardiovascular function. Indeed, when is administered in the RVLM mimic the hypotension of clonidine. Recent findings have shown that imidazoline drugs also exerts biological response directly on the cardiovascular tissues, which can contribute to their antihypertensive response. Currently, new imidazoline receptors ligands are in development. In the present review, we provide a brief update on the cardiovascular effects of clonidine, moxonidine, rilmenidine, and the novel imidazol...
Source: Cardiovascular and Hematological Disorders Drug Targets - Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

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Hello: New to this forum. I am a board certified Pain Medicine MD. I have been seeing patients that are interested in stellate ganglion blocks (cervical sympathetic chain) for PTSD, depression, anxiety, etc. Most of these patients found my practice due to the specificity/complexity of this procedure. Apparently, a '60minutes' CBS piece and a Podcast has sparked interest in this procedure for the aforementioned conditions. I have done my due diligence and cannot find literature... PTSD and Stellate Ganglion Blocks
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Psychiatry Source Type: forums
By Sandee LaMotte, CNN (CNN) — Many of us begin to groan and moan as our precious weekend comes to an end. It’s not just the interruption of fun with friends and family that triggers the Sunday blues, or what some call the Sunday scaries. It’s also anxiety and dread about the workweek to come. One study found 81% of more than 1,000 respondents said they became progressively more anxious as their restful Sunday came to a close. Psychologists call it “anticipatory anxiety.” Nearly two-thirds reported a restless night’s sleep Sunday night, which they attributed to job-related anxi...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Featured Health News CNN Mental Health Source Type: news
CONCLUSIONS: The study findings suggest that resilience is a significant prospective predictor of psychological and social function over time in individuals with chronic physical disabilities. PMID: 31674642 [PubMed - as supplied by publisher]
Source: Annals of Behavioral Medicine - Category: Psychiatry & Psychology Authors: Tags: Ann Behav Med Source Type: research
Publication date: Available online 30 October 2019Source: Physiology &BehaviorAuthor(s): T.S. Souto, F.S.N. Nakao, C.A. Giriko, C.T. dias, A.I.P Cheberle, R.H. lambertucci, C. Mendes-da-SilvaAbstractHigh-fat diets (HFDs) during pregnancy may damage the neural development and emotional behavior of rat offspring. Therefore, we investigated the neurobehavioral development of rat offspring who were fed a control diet (CD) or an HFD with lard (HFD-lard) or canola oil (HFD-canola oil), during pregnancy. Offspring's neurodevelopment (somatic growth, physical maturation, and ontogenesis reflex) was assessed while they were suc...
Source: Physiology and Behavior - Category: Physiology Source Type: research
Authors: Bondoc EN, Marinescu D, Marinescu I, Mălin RD, Stanca L, Zăvoi RE Abstract Epidemiological data confirm the rising incidence of depression associated with suicidal ideation and cardiovascular comorbidities of coronary type. In contradiction with the large number of antidepressant drugs, the therapeutic results are not satisfactory, with numerous existing incomplete remissions characterized by maintained cellular dysfunctionalities that amplify the cognitive deterioration and the risk of several somatic comorbidities. The surprising fact is the relatively high number of deaths in this type of patients due...
Source: Romanian Journal of Morphology and Embryology - Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research
This study provides novel evidence of increased H ‐reflex excitability in a mouse model of diet‐induced obesity. Sex differences in the time course of the reduction in rate‐dependent depression of the H Reflex suggest males respond with an early increase in H‐reflex excitability, whereas females show a progressive increase in reflex excitab ility. AbstractObesity is associated with balance and motor control deficits. We have recently shown that Group Ia muscle spindle afferents, the sensory arm of the muscle stretch reflex, are less responsive in mice fed a high ‐fat diet. Here we test the hypothesis that reflex ...
Source: Physiological Reports - Category: Physiology Authors: Tags: Original Research Source Type: research
Psychological stress is recognized as a major modifiable risk factor for adult non-communicable disease (NCD) that includes depression, type 2 diabetes mellitus, and cardiovascular disease. Dysregulation of hypothalamic-pituitary-adrenal (HPA) axis activity resulting in either exaggerated or blunted cortisol responses, and altered autonomic cardiovascular control have been thought to underlie this association. The developmental origins hypothesis proposes that impaired nutrition during fetal and early postnatal growth is associated with a higher NCD risk later in life. Maternal nutrients are vital for fetal growth and deve...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Our world has never witnessed a time of greater promise for improving human health. Many of today’s health advances have stemmed from a long arc of discovery that begins with strong, steady support for basic science. In large part because of fundamental research funded by the National Institutes of Health (NIH), which traces its roots to 1887, Americans are living longer, healthier lives. Life expectancy for a baby born in the U.S. has risen from 47 years in 1900 to more than 78 years today. Among the advances that have helped to make this possible are a 70% decline in the U.S. death rate from cardiovascular disease ...
Source: TIME: Science - Category: Science Authors: Tags: Uncategorized Healthcare medicine Source Type: news
ConclusionOur data demonstrate that DEX sedation carries a potential risk of aspiration due to swallowing reflex depression during elevation of the larynx; therefore, suctioning of water and saliva should be rigorously performed. However, peripheral muscle contraction of the submental muscle complex, neural organization function, and timing of the swallowing reflex in relation to the respiratory cycle are not affected.
Source: Journal of Dental Sciences - Category: Dentistry Source Type: research
This is by one of ouroutstanding 3rd year residents, Aaron Robinson, with some edits and comments by SmithEMS responded to a reported seizure in a 42 year old male. Per bystanders, he went down after some intense sporting activity, and had “shaking” type movement. He reports no personal or familial history of seizures.One of our EMS Fellows along with a Senior EM Resident were on duty that evening, and arrived on the scene with the Fire Department. When the physicians approached him, he was ashen, diaphoretic, and appeared in shock. Fire was able to obtain a BP of 60/palp and a pulse in the 40s. The physicians ...
Source: Dr. Smith's ECG Blog - Category: Cardiology Authors: Source Type: blogs
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