Autonomic imbalance in cardiac surgery: a potential determinant of the failure in remote ischemic preconditioning

Remote ischemic preconditioning (RIPC) is a cardioprotective strategy against myocardial damage by ischemia-reperfusion. Many in-vivo and ex-vivo animal researches have demonstrated that RIPC decreases significantly the ischemia-reperfusion myocardial damage, by up to 58% in isolated rat heart. Cardiac artery bypass graft surgery (CABG) is a clinical model of myocardial ischemia-reperfusion and a clinical potential application to RIPC. However, although RIPC has shown successful results in experimental studies, clinical trials on CABG have failed to demonstrate a benefit of RIPC in humans.

Source: Medical Hypotheses - July 2, 2018 Category: Biomedical Science Authors: Abraham I.J. Gajardo, Lukas Karachon, Pablo Bustamante, Pablo Repullo, Marcelo Llancaqueo, Gina S ánchez, Ramón Rodrigo Source Type: research