Neurobiology of cognitive remediation in schizophrenia: Effects of EAAT2 polymorphism

Cognitive deficits represent core features of schizophrenia, affecting quality of life and functioning. The excitatory amino acid transporter 2 (EAAT2) is responsible for the majority of glutamate reuptake and its activity is crucial for glutamatergic neurotransmission, prevention of excitotoxic damage and cerebral metabolism. Different studies reported that EAAT2 rs4354668 ( −181 T/G) influences cognitive functions and brain structures in patients with schizophrenia. Specifically, the G allele, linked to lower EAAT2 expression, was associated with impaired prefrontal cognitive performance and reduced grey matter volumes.

Source: Schizophrenia Research - July 2, 2018 Category: Psychiatry Authors: Marco Spangaro, Marta Bosia, Margherita Bechi, Mariachiara Buonocore, Federica Cocchi, Carmelo Guglielmino, Laura Bianchi, Antonella Mastromatteo, Cristina Lorenzi, Roberto Cavallaro Source Type: research